but-3-enoic acid [3-(2-{3-[(allylmethylamino)methyl]phenylamino}pyrimidin-4-yl)phenyl]amide

Base Information

Chemical Name:but-3-enoic acid [3-(2-{3-[(allylmethylamino)methyl]phenylamino}pyrimidin-4-yl)phenyl]amide
CAS No.:1354567-47-7
Molecular Formula:C₂₅H₂₇N₅O
Molecular Weight:413.522
Hs Code.:

Synonyms:but-3-enoic acid [3-(2-{3-[(allylmethylamino)methyl]phenylamino}pyrimidin-4-yl)phenyl]amide

Suppliers and Price of but-3-enoic acid [3-(2-{3-[(allylmethylamino)methyl]phenylamino}pyrimidin-4-yl)phenyl]amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of but-3-enoic acid [3-(2-{3-[(allylmethylamino)methyl]phenylamino}pyrimidin-4-yl)phenyl]amide

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Technology Process of but-3-enoic acid [3-(2-{3-[(allylmethylamino)methyl]phenylamino}pyrimidin-4-yl)phenyl]amide

There total 6 articles about but-3-enoic acid [3-(2-{3-[(allylmethylamino)methyl]phenylamino}pyrimidin-4-yl)phenyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 937271-56-2
3-[(allylmethylamino)methyl]phenylamine

: 1354566-63-4
but-3-enoic acid [3-(2-chloropyrimidin-4-yl)phenyl]amide

: 1354567-47-7
but-3-enoic acid [3-(2-{3-[(allylmethylamino)methyl]phenylamino}pyrimidin-4-yl)phenyl]amide

Guidance literature:: With hydrogenchloride; In water; butan-1-ol; at 90 - 100 ℃;
DOI:10.1021/jm201112g

Reference yield:

: 859516-82-8
2-chloro-4-(3-aminophenyl)-pyrimidine

: 1354567-47-7
but-3-enoic acid [3-(2-{3-[(allylmethylamino)methyl]phenylamino}pyrimidin-4-yl)phenyl]amide

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

2: hydrogenchloride / water; butan-1-ol / 90 - 100 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; butan-1-ol;
DOI:10.1021/jm201112g

Reference yield:

: 859516-81-7
2-chloro-4-(3-nitrophenyl)pyrimidine

: 1354567-47-7
but-3-enoic acid [3-(2-{3-[(allylmethylamino)methyl]phenylamino}pyrimidin-4-yl)phenyl]amide

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; tin(II) chloride hydrate / dichloromethane / 7 h / 0 - 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

3: hydrogenchloride / water; butan-1-ol / 90 - 100 °C

With hydrogenchloride; methanol; tin(II) chloride hydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; butan-1-ol;
DOI:10.1021/jm201112g