5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl pyrimidine-2-carboxamide

Base Information

Chemical Name:5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl pyrimidine-2-carboxamide
CAS No.:1419598-86-9
Molecular Formula:C₂₈H₂₉ClN₆O₂
Molecular Weight:517.03
Hs Code.:

Synonyms:5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl pyrimidine-2-carboxamide

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Chemical Property of 5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl pyrimidine-2-carboxamide

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Technology Process of 5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl pyrimidine-2-carboxamide

There total 4 articles about 5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl pyrimidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1254713-63-7
(3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methanamine

: 1419603-42-1
2-(2-(phenylcarbamoyl)pyrimidin-5-yl)propanoic acid

: 1419598-86-9
5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl pyrimidine-2-carboxamide

Guidance literature:: With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 36h;

Reference yield:

: 37131-87-6
5-bromo-2-pyrimidinecarboxylic acid

: 1419598-86-9
5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / benzene / 2 h / 100 °C

2.1: dichloromethane / 16 h / 23 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / -5 °C

3.2: 2 h / -5 - 23 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 16 h / Inert atmosphere; Reflux

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene / 16 h / Reflux; Inert atmosphere

6.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 2585.81 Torr / Inert atmosphere

7.1: hydrogenchloride; water / ethanol / 2 h / 90 °C

8.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 36 h

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; palladium 10% on activated carbon; water; hydrogen; potassium acetate; sodium hydride; sodium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil; benzene;

Reference yield:

: 1013335-78-8
5-bromopyridine-2-carboxylic acid chloride

: 1419598-86-9
5-(1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 16 h / 23 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / -5 °C

2.2: 2 h / -5 - 23 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 16 h / Inert atmosphere; Reflux

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene / 16 h / Reflux; Inert atmosphere

5.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 2585.81 Torr / Inert atmosphere

6.1: hydrogenchloride; water / ethanol / 2 h / 90 °C

7.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 36 h

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; potassium acetate; sodium hydride; sodium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;