N⁽¹⁾-(4-butylphenyl)-N⁽²⁾-(4-(hydroxymethyl)phenyl)phthalamide

Base Information

• Chemical Name: N⁽¹⁾-(4-butylphenyl)-N⁽²⁾-(4-(hydroxymethyl)phenyl)phthalamide
• CAS No.: 1253889-41-6
• Molecular Formula: C₂₅H₂₆N₂O₃
• Molecular Weight: 402.493
• Mol file: 1253889-41-6.mol

Synonyms:N⁽¹⁾-(4-butylphenyl)-N⁽²⁾-(4-(hydroxymethyl)phenyl)phthalamide

Chemical Property of N⁽¹⁾-(4-butylphenyl)-N⁽²⁾-(4-(hydroxymethyl)phenyl)phthalamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁽¹⁾-(4-butylphenyl)-N⁽²⁾-(4-(hydroxymethyl)phenyl)phthalamide

There total 3 articles about N⁽¹⁾-(4-butylphenyl)-N⁽²⁾-(4-(hydroxymethyl)phenyl)phthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-(4-butylphenylimino)isobenzofuran-1(3H)-one (1253889-37-0) + 4-aminobenzenemethanol (623-04-1) → N(1)-(4-butylphenyl)-N(2)-(4-(hydroxymethyl)phenyl)phthalamide (1253889-41-6)

Guidance literature:

In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201002958

Reference yield:

2-(4-butylphenylcarbamoyl)benzoic acid (19543-72-7) → N(1)-(4-butylphenyl)-N(2)-(4-(hydroxymethyl)phenyl)phthalamide (1253889-41-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; trifluoroacetic anhydride / 1,4-dioxane / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran / 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1002/chem.201102018

Reference yield:

4-Butylaniline (104-13-2) → N(1)-(4-butylphenyl)-N(2)-(4-(hydroxymethyl)phenyl)phthalamide (1253889-41-6)

Guidance literature:

Multi-step reaction with 3 steps

1: chloroform / 3 h / Inert atmosphere; Reflux

2: triethylamine; trifluoroacetic anhydride / 1,4-dioxane / 0 - 20 °C / Inert atmosphere

3: tetrahydrofuran / 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; chloroform;

DOI:10.1002/chem.201102018

upstream raw materials:

3-(4-butylphenylimino)isobenzofuran-1(3H)-one

4-aminobenzenemethanol

2-(4-butylphenylcarbamoyl)benzoic acid

4-Butylaniline