(S)-1-(4-(4-(5-fluoro-2-(methylsulfonyl)phenyl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-methylurea

Base Information

Chemical Name:(S)-1-(4-(4-(5-fluoro-2-(methylsulfonyl)phenyl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-methylurea
CAS No.:1428531-94-5
Molecular Formula:C₂₃H₂₅FN₆O₄S
Molecular Weight:500.554
Hs Code.:

Synonyms:(S)-1-(4-(4-(5-fluoro-2-(methylsulfonyl)phenyl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-methylurea

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Chemical Property of (S)-1-(4-(4-(5-fluoro-2-(methylsulfonyl)phenyl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-methylurea

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Technology Process of (S)-1-(4-(4-(5-fluoro-2-(methylsulfonyl)phenyl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-methylurea

There total 5 articles about (S)-1-(4-(4-(5-fluoro-2-(methylsulfonyl)phenyl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1428532-50-6
(S)-1-(4-(4-(5-fluoro-2-(methylthio)phenyl)-6-(3-methylmorpholin-4-yl)-1,3,5-triazin-2-yl)phenyl)-3-methylurea

: 1428531-94-5
(S)-1-(4-(4-(5-fluoro-2-(methylsulfonyl)phenyl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-methylurea

Guidance literature:: With Oxone; In tetrahydrofuran; methanol; water; at 0 - 20 ℃;

Reference yield:

: 350595-57-2
(S)-3-methylmorpholine

: 1428531-94-5
(S)-1-(4-(4-(5-fluoro-2-(methylsulfonyl)phenyl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-methylurea

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 0.33 h / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane / 1.5 h / 90 °C / Microwave irradiation

3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane / 1 h / 100 °C / Microwave irradiation

4: Oxone / tetrahydrofuran; methanol; water / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; Oxone; sodium carbonate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; 2: |Suzuki-Miyaura Coupling / 3: |Suzuki Coupling;

Reference yield:

: 1428532-47-1
(S)-4-(4,6-dichloro-1,3,5-triazin-2-yl)-3-methylmorpholine

: 1428531-94-5
(S)-1-(4-(4-(5-fluoro-2-(methylsulfonyl)phenyl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-methylurea

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane / 1.5 h / 90 °C / Microwave irradiation

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane / 1 h / 100 °C / Microwave irradiation

3: Oxone / tetrahydrofuran; methanol; water / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; Oxone; sodium carbonate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; 1: |Suzuki-Miyaura Coupling / 2: |Suzuki Coupling;