5'-O-Acryloyl-2',3'-O-isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine

Base Information

Chemical Name:5'-O-Acryloyl-2',3'-O-isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine
CAS No.:129141-70-4
Molecular Formula:C₂₃H₂₅FN₂O₈
Molecular Weight:476.459
Hs Code.:

Synonyms:5'-O-Acryloyl-2',3'-O-isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-Acryloyl-2',3'-O-isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine

Chemical Property:

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Technology Process of 5'-O-Acryloyl-2',3'-O-isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine

There total 4 articles about 5'-O-Acryloyl-2',3'-O-isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 129141-66-8
2',3'-O-Isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine

: 814-68-6,25189-84-8
acryloyl chloride

: 129141-70-4
5'-O-Acryloyl-2',3'-O-isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1246/cl.1990.339

Reference yield:

: 2797-17-3
2',3'-O-isopropylidene-5-fluorouridine

: 129141-70-4
5'-O-Acryloyl-2',3'-O-isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / N,N-diisopropylethylamine / acetonitrile / 3 h / Ambient temperature

2: 96 percent / N,N-diisopropylethylamine / acetonitrile / 4 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1246/bcsj.64.2266

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 129141-70-4
5'-O-Acryloyl-2',3'-O-isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / N,N-diisopropylethylamine / acetonitrile / 3 h / Ambient temperature

2: 96 percent / N,N-diisopropylethylamine / acetonitrile / 4 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1246/bcsj.64.2266