Technology Process of (2S,5S)-2-Methyl-3,5-diphenyl-2-[4-(tetrahydro-pyran-2-yloxy)-butyl]-2,5-dihydro-1H-pyrrole
There total 8 articles about (2S,5S)-2-Methyl-3,5-diphenyl-2-[4-(tetrahydro-pyran-2-yloxy)-butyl]-2,5-dihydro-1H-pyrrole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride; aluminium trichloride;
In
diethyl ether;
at 0 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 72 percent / p-toluene sulfonic acid / CH2Cl2
2: 1.4 M n-butyllithium / tetrahydrofuran; hexane
3: 100 percent / 24 h
4: 87 percent / sodium hydride / propan-2-ol / 6.5 h / Ambient temperature
5: 51 percent / sodium hydride / dimethylsulfoxide / 18 h / Ambient temperature
6: 94 percent / aluminium chloride, lithium-aluminium hydride / diethyl ether / 2 h / 0 °C
With
lithium aluminium tetrahydride; n-butyllithium; aluminium trichloride; sodium hydride; toluene-4-sulfonic acid;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.4 M n-butyllithium / tetrahydrofuran; hexane
2: 100 percent / 24 h
3: 87 percent / sodium hydride / propan-2-ol / 6.5 h / Ambient temperature
4: 51 percent / sodium hydride / dimethylsulfoxide / 18 h / Ambient temperature
5: 94 percent / aluminium chloride, lithium-aluminium hydride / diethyl ether / 2 h / 0 °C
With
lithium aluminium tetrahydride; n-butyllithium; aluminium trichloride; sodium hydride;
In
tetrahydrofuran; diethyl ether; hexane; dimethyl sulfoxide; isopropyl alcohol;
