Preclamol hydrochloride

Base Information

Chemical Name:Preclamol hydrochloride
CAS No.:88768-67-6
Molecular Formula:C14H21 N O . Cl H
Molecular Weight:255.788
Hs Code.:2933399090
UNII:Q8W2T87WWW
DSSTox Substance ID:DTXSID401017949
Wikidata:Q27287121
ChEMBL ID:CHEMBL1255842
Mol file:88768-67-6.mol

Synonyms:PRECLAMOL HYDROCHLORIDE;88768-67-6;S(-)-3PPP hydrochloride;UNII-Q8W2T87WWW;Q8W2T87WWW;S(-)-3-PPP HCl;Preclamol (hydrochloride);(S)-(-)-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride;3-[(3S)-1-propylpiperidin-3-yl]phenol;hydrochloride;Phenol, 3-(1-propyl-3-piperidinyl)-, hydrochloride, (S)-;(-)-Preclamol hydrochloride;S(-)-3-PPP-HCl;MLS002153168;SCHEMBL3692396;(-)-3PPP HYDROCHLORIDE;CHEMBL1255842;DTXSID401017949;Tox21_500996;AKOS024418759;CCG-222300;LP00996;NCGC00261681-01;SMR000326863;HY-108698;CS-0030118;EU-0100996;P-103;Q27287121;(S)-()-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride;(S)-(-)-3-(HYDROXYPHENYL)-N-PROPYLPIPERIDINE HYDROCHLORIDE;(S)-(-)-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride, >=98% (HPLC), solid

Suppliers and Price of Preclamol hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-(-)-3-(3-Hydroxyphenyl)-N-propylpiperidineHydrochloride
10mg
$ 1440.00

Total 3 raw suppliers

Chemical Property of Preclamol hydrochloride

Chemical Property:

Vapor Pressure:3.85E-05mmHg at 25°C
Boiling Point:342.2°C at 760 mmHg
Flash Point:158°C
PSA：23.47000
LogP:3.72150
Solubility.:H2O: 150 mg/mL Solutions should be freshly prepared.
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:255.1389920
Heavy Atom Count:17
Complexity:207

Purity/Quality:: (S)-(-)-3-(3-Hydroxyphenyl)-N-propylpiperidineHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCN1CCCC(C1)C2=CC(=CC=C2)O.Cl
Isomeric SMILES:CCCN1CCC[C@H](C1)C2=CC(=CC=C2)O.Cl
Uses (S)-(-)-3-(3-Hydroxyphenyl)-N-propylpiperidine Hydrochloride is a dopamine autoreceptor agonist.

Technology Process of Preclamol hydrochloride

There total 7 articles about Preclamol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85966-89-8
preclamol

: 88768-67-6
(-)-3-PPP hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol;
DOI:10.1016/j.tetlet.2016.12.051

Reference yield:

: (+)-(2S,3S)-tert-butyl 2-(tert-butoxycarbonyl(quinolin-8-yl)carbamoyl)-3-(3-methoxyphenyl)piperidine-1-carboxylate

: 88768-67-6
(-)-3-PPP hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hydroxide monohydrate; dihydrogen peroxide / water; tetrahydrofuran / 40.3 h / 0 - 20 °C

2.1: 4-methyl-morpholine / tetrahydrofuran / 1 h / -10 - 20 °C

2.2: 12.3 h / -10 - 20 °C

3.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 2 h / 80 °C / Inert atmosphere

4.1: trifluoroacetic acid / 2 h / 20 °C

5.1: potassium carbonate / acetonitrile / 7 h / 80 °C

6.1: hydrogen bromide / 2 h / 120 °C / Inert atmosphere

7.1: hydrogenchloride / ethanol

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide monohydrate; 2,2'-azobis(isobutyronitrile); hydrogen bromide; dihydrogen peroxide; tri-n-butyl-tin hydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; ethanol; water; toluene; acetonitrile;
DOI:10.1016/j.tetlet.2016.12.051

Reference yield:

: 3105-95-1,83680-83-5
pipecolinic acid

: 88768-67-6
(-)-3-PPP hydrochloride

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hydroxide / water; 1,4-dioxane / 0 - 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 36 h / 20 °C

3.1: palladium diacetate; silver(I) acetate / toluene / 12 h / 100 °C / Sealed tube

4.1: dmap / acetonitrile / 16 h / 70 °C

5.1: lithium hydroxide monohydrate; dihydrogen peroxide / water; tetrahydrofuran / 40.3 h / 0 - 20 °C

6.1: 4-methyl-morpholine / tetrahydrofuran / 1 h / -10 - 20 °C

6.2: 12.3 h / -10 - 20 °C

7.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 2 h / 80 °C / Inert atmosphere

8.1: trifluoroacetic acid / 2 h / 20 °C

9.1: potassium carbonate / acetonitrile / 7 h / 80 °C

10.1: hydrogen bromide / 2 h / 120 °C / Inert atmosphere

11.1: hydrogenchloride / ethanol

With 4-methyl-morpholine; hydrogenchloride; dmap; lithium hydroxide monohydrate; 2,2'-azobis(isobutyronitrile); hydrogen bromide; dihydrogen peroxide; tri-n-butyl-tin hydride; silver(I) acetate; palladium diacetate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene; acetonitrile;
DOI:10.1016/j.tetlet.2016.12.051