3′-O-(P-(2-cyanoethoxy)-N,N′-diisopropylaminophosphinyl)-5′-(4,4′-dimethoxytrityl)-5-phenyl-2′-deoxyuridine

Base Information

Chemical Name:3′-O-(P-(2-cyanoethoxy)-N,N′-diisopropylaminophosphinyl)-5′-(4,4′-dimethoxytrityl)-5-phenyl-2′-deoxyuridine
CAS No.:1574218-98-6
Molecular Formula:C₄₅H₅₁N₄O₈P
Molecular Weight:806.896
Hs Code.:

Synonyms:3′-O-(P-(2-cyanoethoxy)-N,N′-diisopropylaminophosphinyl)-5′-(4,4′-dimethoxytrityl)-5-phenyl-2′-deoxyuridine

Suppliers and Price of 3′-O-(P-(2-cyanoethoxy)-N,N′-diisopropylaminophosphinyl)-5′-(4,4′-dimethoxytrityl)-5-phenyl-2′-deoxyuridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3′-O-(P-(2-cyanoethoxy)-N,N′-diisopropylaminophosphinyl)-5′-(4,4′-dimethoxytrityl)-5-phenyl-2′-deoxyuridine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3′-O-(P-(2-cyanoethoxy)-N,N′-diisopropylaminophosphinyl)-5′-(4,4′-dimethoxytrityl)-5-phenyl-2′-deoxyuridine

There total 4 articles about 3′-O-(P-(2-cyanoethoxy)-N,N′-diisopropylaminophosphinyl)-5′-(4,4′-dimethoxytrityl)-5-phenyl-2′-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1574218-93-1
5′-(4,4′-dimethoxytrityloxymethyl)-5-phenyl-2′-deoxyuridine

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 1574218-98-6
3′-O-(P-(2-cyanoethoxy)-N,N′-diisopropylaminophosphinyl)-5′-(4,4′-dimethoxytrityl)-5-phenyl-2′-deoxyuridine

Guidance literature:: With N,N-diisopropylamine tetrazolide; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo4025896

Reference yield:

: 54-42-2,162239-35-2
5-Iodo-2'-deoxyuridine

: 1574218-98-6
3′-O-(P-(2-cyanoethoxy)-N,N′-diisopropylaminophosphinyl)-5′-(4,4′-dimethoxytrityl)-5-phenyl-2′-deoxyuridine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide; sodium tetrachloropalladate(II) / water / 100 °C / Microwave irradiation

2: pyridine / acetonitrile / 4 h / 20 °C / Inert atmosphere

3: N,N-diisopropylamine tetrazolide / dichloromethane / 2 h / 20 °C / Inert atmosphere

With pyridine; sodium tetrachloropalladate(II); N,N-diisopropylamine tetrazolide; potassium hydroxide; In dichloromethane; water; acetonitrile; 1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jo4025896

Reference yield:

: 98-80-6
phenylboronic acid

: 1574218-98-6
3′-O-(P-(2-cyanoethoxy)-N,N′-diisopropylaminophosphinyl)-5′-(4,4′-dimethoxytrityl)-5-phenyl-2′-deoxyuridine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide; sodium tetrachloropalladate(II) / water / 100 °C / Microwave irradiation

2: pyridine / acetonitrile / 4 h / 20 °C / Inert atmosphere

3: N,N-diisopropylamine tetrazolide / dichloromethane / 2 h / 20 °C / Inert atmosphere

With pyridine; sodium tetrachloropalladate(II); N,N-diisopropylamine tetrazolide; potassium hydroxide; In dichloromethane; water; acetonitrile; 1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jo4025896