((E)-(2R,3R)-2,3-Bis-benzyloxy-6-methyl-hept-4-enyloxy)-triisopropyl-silane

Base Information

Chemical Name:((E)-(2R,3R)-2,3-Bis-benzyloxy-6-methyl-hept-4-enyloxy)-triisopropyl-silane
CAS No.:430473-69-1
Molecular Formula:C₃₁H₄₈O₃Si
Molecular Weight:496.806
Hs Code.:

Synonyms:((E)-(2R,3R)-2,3-Bis-benzyloxy-6-methyl-hept-4-enyloxy)-triisopropyl-silane

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Chemical Property of ((E)-(2R,3R)-2,3-Bis-benzyloxy-6-methyl-hept-4-enyloxy)-triisopropyl-silane

Chemical Property:

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Technology Process of ((E)-(2R,3R)-2,3-Bis-benzyloxy-6-methyl-hept-4-enyloxy)-triisopropyl-silane

There total 5 articles about ((E)-(2R,3R)-2,3-Bis-benzyloxy-6-methyl-hept-4-enyloxy)-triisopropyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67219-32-3
2-[(2-methylpropyl)sulfonyl]benzothiazole

: 1026450-96-3
(2S,3R)-2,3-Bis-benzyloxy-4-triisopropylsilanyloxy-butyraldehyde

: 430473-69-1
((E)-(2R,3R)-2,3-Bis-benzyloxy-6-methyl-hept-4-enyloxy)-triisopropyl-silane

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 1h;
DOI:10.1016/S0040-4039(02)00022-9

Reference yield:

: 100-39-0
benzyl bromide

: 430473-69-1
((E)-(2R,3R)-2,3-Bis-benzyloxy-6-methyl-hept-4-enyloxy)-triisopropyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / NaH; nBu₄NI / tetrahydrofuran / 20 °C

2: 86 percent / LAH / tetrahydrofuran / 20 °C

3: 92 percent / NaH; nBu₄NI / tetrahydrofuran

4: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

5: LHMDS / tetrahydrofuran / 1 h / -78 - 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; tetra-(n-butyl)ammonium iodide; sodium hydride; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 5: Julia olefination;
DOI:10.1016/S0040-4039(02)00022-9

Reference yield:

: 113350-84-8
(2R,3R)-(-)-2,3-bis(phenylmethoxy)-1,4-butanediol

: 430473-69-1
((E)-(2R,3R)-2,3-Bis-benzyloxy-6-methyl-hept-4-enyloxy)-triisopropyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / NaH; nBu₄NI / tetrahydrofuran

2: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

3: LHMDS / tetrahydrofuran / 1 h / -78 - 20 °C

With oxalyl dichloride; tetra-(n-butyl)ammonium iodide; sodium hydride; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 3: Julia olefination;
DOI:10.1016/S0040-4039(02)00022-9