Technology Process of (1S,2S,E)-2-methyl-1,6-diphenylhex-3-en-1-amine
There total 3 articles about (1S,2S,E)-2-methyl-1,6-diphenylhex-3-en-1-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
benzaldehyde;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran; diethyl ether;
at -10 ℃;
Inert atmosphere;
With
titanium(IV) isopropylate;
In
tetrahydrofuran; diethyl ether;
for 0.0833333h;
Inert atmosphere;
(S)-(Z)-1-phenyl-4-hexen-3-ol;
optical yield given as %ee;
stereoselective reaction;
Further stages;
DOI:10.1021/ja202900h
- Guidance literature:
-
N-benzylidene-1,1,1-trimethylsilanamine;
With
titanium(IV) isopropylate;
In
tetrahydrofuran; diethyl ether;
at -10 ℃;
for 0.0833333h;
Irradiation;
With
cyclohexylmagnesiumchloride;
In
tetrahydrofuran; diethyl ether;
at -78 - -40 ℃;
for 1.78333h;
Inert atmosphere;
C12H15O(1-)*Li(1+);
In
tetrahydrofuran; diethyl ether;
at -40 - 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1039/c3cc45607b
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diethyl ether; tetrahydrofuran / 0.33 h / -10 °C / Inert atmosphere
2.1: titanium(IV) isopropylate / diethyl ether; tetrahydrofuran / 0.08 h / -10 °C / Irradiation
2.2: 1.78 h / -78 - -40 °C / Inert atmosphere
2.3: 2 h / -40 - 20 °C / Inert atmosphere
With
titanium(IV) isopropylate;
In
tetrahydrofuran; diethyl ether;
DOI:10.1039/c3cc45607b
