(5-methyl-4H-pyrroIo[2,3-d]thiazol-6-yl)(2-(pyrrolidin-1-ylsulfonyl)phenyI)methanol

Base Information

Chemical Name:(5-methyl-4H-pyrroIo[2,3-d]thiazol-6-yl)(2-(pyrrolidin-1-ylsulfonyl)phenyI)methanol
CAS No.:1355613-58-9
Molecular Formula:C₁₇H₁₉N₃O₃S₂
Molecular Weight:377.488
Hs Code.:

Synonyms:(5-methyl-4H-pyrroIo[2,3-d]thiazol-6-yl)(2-(pyrrolidin-1-ylsulfonyl)phenyI)methanol

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Chemical Property of (5-methyl-4H-pyrroIo[2,3-d]thiazol-6-yl)(2-(pyrrolidin-1-ylsulfonyl)phenyI)methanol

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Technology Process of (5-methyl-4H-pyrroIo[2,3-d]thiazol-6-yl)(2-(pyrrolidin-1-ylsulfonyl)phenyI)methanol

There total 1 articles about (5-methyl-4H-pyrroIo[2,3-d]thiazol-6-yl)(2-(pyrrolidin-1-ylsulfonyl)phenyI)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1219449-45-2
2-(pyrrolidin-1-ylsulfonyl)benzaldehyde

: 1327366-69-7
5-methyl-4H-pyrrolo[2,3-d]thiazole

: 1355613-58-9
(5-methyl-4H-pyrroIo[2,3-d]thiazol-6-yl)(2-(pyrrolidin-1-ylsulfonyl)phenyI)methanol

Guidance literature:: With water; sodium hydroxide; In N,N-dimethyl-formamide; at 25 - 55 ℃;

Reference yield: 8.5%

: 1355613-58-9
(5-methyl-4H-pyrroIo[2,3-d]thiazol-6-yl)(2-(pyrrolidin-1-ylsulfonyl)phenyI)methanol

: 1355613-59-0
5-methyl-6-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-4H-pyrrolo[2,3-d]thiazole

Guidance literature:: (5-methyl-4H-pyrroIo[2,3-d]thiazol-6-yl)(2-(pyrrolidin-1-ylsulfonyl)phenyI)methanol; With triethylsilane; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃; for 65h;

With sodium hydrogencarbonate; In Dichlorodifluoromethane; water;

Reference yield:

: 1355613-58-9
(5-methyl-4H-pyrroIo[2,3-d]thiazol-6-yl)(2-(pyrrolidin-1-ylsulfonyl)phenyI)methanol

: 1355613-61-4
ethyl 2-(5-methyl-6-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-4H-pyrrolo[2,3-d]thiazol-4-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilyl trifluoromethanesulfonate; triethylsilane / dichloromethane / 65 h / 0 °C

2: potassium carbonate; potassium iodide / acetonitrile / 3 h / 90 °C / Sealed vial; Inert atmosphere

With triethylsilane; trimethylsilyl trifluoromethanesulfonate; potassium carbonate; potassium iodide; In dichloromethane; acetonitrile;