C₁₆H₂₁NO₆

Base Information

• Chemical Name: C₁₆H₂₁NO₆
• CAS No.: 119153-86-5
• Molecular Formula: C₁₆H₂₁NO₆
• Molecular Weight: 323.346
• Mol file: 119153-86-5.mol

Synonyms:C₁₆H₂₁NO₆

Chemical Property of C₁₆H₂₁NO₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₂₁NO₆

There total 3 articles about C₁₆H₂₁NO₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N-(benzyloxycarbonyl)valine (1149-26-4) + chloroformic acid ethyl ester (541-41-3) → C16H21NO6 (119153-86-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 5 ℃; for 1h;

DOI:10.1021/jm00082a005

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → C16H21NO6 (119153-86-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / water / Inert atmosphere

2: triethylamine / Inert atmosphere

With sodium hydrogencarbonate; triethylamine; In water;

DOI:10.1039/c2ob26828k

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → C16H21NO6 (119153-86-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / water / Inert atmosphere

2: triethylamine / Inert atmosphere

With sodium hydrogencarbonate; triethylamine; In water;

DOI:10.1039/c2ob26828k

upstream raw materials:

(S)-N-(benzyloxycarbonyl)valine

chloroformic acid ethyl ester

benzyl chloroformate

L-valine

Downstream raw materials:

(S)-N-benzyloxycarbonylvalinamide

benzyl (S)-(1-hydrazineyl-3-methyl-1-oxobutan-2-yl)carbamate

benzyl (S)-(1-diazo-4-methyl-2-oxopentan-3-yl)carbamate

benzyl (2S,3R)-2-isopropyl-5-oxopyrrolidin-3-ylcarbamate

Refernces

• 1、 Brown, Alexander J.,Clarke, Paul A.,Vagkidis, Nikolaos. "Evaluation of Amino Nitriles and an Amino Imidate as Organo?-catalysts in Aldol Reactions". . p. 4106 - 4112. Retrieved 2019/10/28.
• 2、 Madhu, Chilakapati,Panguluri, Nageswara Rao,Sureshbabu, Vommina V.. "Synthesis of Nα-Z protected amino alkyl triazole acids and their application to neo-glycopeptides synthesis". . p. 858 - 864. Retrieved 2014/08/05.