4-((E)-3-(2-(2-((E)-3-(4-acetoxy-3-methoxyphenyl)acryloyloxy)ethoxy)ethylamino)-3-oxoprop-1-enyl)-1,2-phenylene diacetate

Base Information

• Chemical Name: 4-((E)-3-(2-(2-((E)-3-(4-acetoxy-3-methoxyphenyl)acryloyloxy)ethoxy)ethylamino)-3-oxoprop-1-enyl)-1,2-phenylene diacetate
• CAS No.: 1254929-47-9
• Molecular Formula: C₂₉H₃₁NO₁₁
• Molecular Weight: 569.565
• Mol file: 1254929-47-9.mol

Synonyms:4-((E)-3-(2-(2-((E)-3-(4-acetoxy-3-methoxyphenyl)acryloyloxy)ethoxy)ethylamino)-3-oxoprop-1-enyl)-1,2-phenylene diacetate

Chemical Property of 4-((E)-3-(2-(2-((E)-3-(4-acetoxy-3-methoxyphenyl)acryloyloxy)ethoxy)ethylamino)-3-oxoprop-1-enyl)-1,2-phenylene diacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((E)-3-(2-(2-((E)-3-(4-acetoxy-3-methoxyphenyl)acryloyloxy)ethoxy)ethylamino)-3-oxoprop-1-enyl)-1,2-phenylene diacetate

There total 4 articles about 4-((E)-3-(2-(2-((E)-3-(4-acetoxy-3-methoxyphenyl)acryloyloxy)ethoxy)ethylamino)-3-oxoprop-1-enyl)-1,2-phenylene diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C17H21NO7 (1254929-61-7) + 4-acetoxy-3-methoxycinnamoyl chloride (50906-12-2) → 4-((E)-3-(2-(2-((E)-3-(4-acetoxy-3-methoxyphenyl)acryloyloxy)ethoxy)ethylamino)-3-oxoprop-1-enyl)-1,2-phenylene diacetate (1254929-47-9)

Guidance literature:

C₁₇H₂₁NO₇; With dmap; In dichloromethane; for 0.25h;

4-acetoxy-3-methoxycinnamoyl chloride; In dichloromethane; for 3h; Cooling with ice;

DOI:10.5012/bkcs.2011.32.8.2593

Reference yield:

(E)-3-(4-acetoxy-3-methoxyphenyl)acrylic acid (2596-47-6,147677-05-2,34749-55-8) → 4-((E)-3-(2-(2-((E)-3-(4-acetoxy-3-methoxyphenyl)acryloyloxy)ethoxy)ethylamino)-3-oxoprop-1-enyl)-1,2-phenylene diacetate (1254929-47-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride

2.1: dmap / dichloromethane / 0.25 h

2.2: 3 h / Cooling with ice

With dmap; thionyl chloride; In dichloromethane;

DOI:10.5012/bkcs.2011.32.8.2593

Reference yield:

3,4-diacetoxycinnamic acid (88623-81-8) → 4-((E)-3-(2-(2-((E)-3-(4-acetoxy-3-methoxyphenyl)acryloyloxy)ethoxy)ethylamino)-3-oxoprop-1-enyl)-1,2-phenylene diacetate (1254929-47-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

2.1: dichloromethane

3.1: dmap / dichloromethane / 0.25 h

3.2: 3 h / Cooling with ice

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.5012/bkcs.2011.32.8.2593

upstream raw materials:

C₁₇H₂₁NO₇

4-acetoxy-3-methoxycinnamoyl chloride

(E)-3-(4-acetoxy-3-methoxyphenyl)acrylic acid

3,4-diacetoxycinnamic acid

Downstream raw materials:

(E)-2-(2-((E)-3-(3,4-dihydroxyphenyl)acrylamido)ethoxy)ethyl 3-(4-hydroxy-3-methoxyphenyl) acrylate