(E)-2-(2-((E)-3-(3,4-dihydroxyphenyl)acrylamido)ethoxy)ethyl 3-(4-hydroxy-3-methoxyphenyl) acrylate

Base Information

• Chemical Name: (E)-2-(2-((E)-3-(3,4-dihydroxyphenyl)acrylamido)ethoxy)ethyl 3-(4-hydroxy-3-methoxyphenyl) acrylate
• CAS No.: 1254929-48-0
• Molecular Formula: C₂₃H₂₅NO₈
• Molecular Weight: 443.453
• Mol file: 1254929-48-0.mol

Synonyms:(E)-2-(2-((E)-3-(3,4-dihydroxyphenyl)acrylamido)ethoxy)ethyl 3-(4-hydroxy-3-methoxyphenyl) acrylate

Chemical Property of (E)-2-(2-((E)-3-(3,4-dihydroxyphenyl)acrylamido)ethoxy)ethyl 3-(4-hydroxy-3-methoxyphenyl) acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(2-((E)-3-(3,4-dihydroxyphenyl)acrylamido)ethoxy)ethyl 3-(4-hydroxy-3-methoxyphenyl) acrylate

There total 5 articles about (E)-2-(2-((E)-3-(3,4-dihydroxyphenyl)acrylamido)ethoxy)ethyl 3-(4-hydroxy-3-methoxyphenyl) acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-((E)-3-(2-(2-((E)-3-(4-acetoxy-3-methoxyphenyl)acryloyloxy)ethoxy)ethylamino)-3-oxoprop-1-enyl)-1,2-phenylene diacetate (1254929-47-9) → (E)-2-(2-((E)-3-(3,4-dihydroxyphenyl)acrylamido)ethoxy)ethyl 3-(4-hydroxy-3-methoxyphenyl) acrylate (1254929-48-0)

Guidance literature:

With hydrazine hydrate; In methanol; at 20 ℃; for 0.5h;

DOI:10.5012/bkcs.2011.32.8.2593

Reference yield:

(E)-3-(4-acetoxy-3-methoxyphenyl)acrylic acid (2596-47-6,147677-05-2,34749-55-8) → (E)-2-(2-((E)-3-(3,4-dihydroxyphenyl)acrylamido)ethoxy)ethyl 3-(4-hydroxy-3-methoxyphenyl) acrylate (1254929-48-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride

2.1: dmap / dichloromethane / 0.25 h

2.2: 3 h / Cooling with ice

3.1: hydrazine hydrate / methanol / 0.5 h / 20 °C

With dmap; thionyl chloride; hydrazine hydrate; In methanol; dichloromethane;

DOI:10.5012/bkcs.2011.32.8.2593

Reference yield:

3,4-diacetoxycinnamic acid (88623-81-8) → (E)-2-(2-((E)-3-(3,4-dihydroxyphenyl)acrylamido)ethoxy)ethyl 3-(4-hydroxy-3-methoxyphenyl) acrylate (1254929-48-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

2.1: dichloromethane

3.1: dmap / dichloromethane / 0.25 h

3.2: 3 h / Cooling with ice

4.1: hydrazine hydrate / methanol / 0.5 h / 20 °C

With dmap; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;

DOI:10.5012/bkcs.2011.32.8.2593

upstream raw materials:

C₁₇H₂₁NO₇

4-acetoxy-3-methoxycinnamoyl chloride

4-((E)-3-(2-(2-((E)-3-(4-acetoxy-3-methoxyphenyl)acryloyloxy)ethoxy)ethylamino)-3-oxoprop-1-enyl)-1,2-phenylene diacetate

(E)-3-(4-acetoxy-3-methoxyphenyl)acrylic acid