2-Benzyl-3-(morpholine-4-sulfonyl)-propionic acid methyl ester

Base Information

• Chemical Name: 2-Benzyl-3-(morpholine-4-sulfonyl)-propionic acid methyl ester
• CAS No.: 147794-61-4
• Molecular Formula: C₁₅H₂₁NO₅S
• Molecular Weight: 327.401
• Mol file: 147794-61-4.mol

Synonyms:2-Benzyl-3-(morpholine-4-sulfonyl)-propionic acid methyl ester

Chemical Property of 2-Benzyl-3-(morpholine-4-sulfonyl)-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzyl-3-(morpholine-4-sulfonyl)-propionic acid methyl ester

There total 4 articles about 2-Benzyl-3-(morpholine-4-sulfonyl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-methyl 2-(bromomethyl)-3-phenylacrylate (103669-71-2) → 2-Benzyl-3-(morpholine-4-sulfonyl)-propionic acid methyl ester (147794-61-4)

Guidance literature:

Multi-step reaction with 4 steps

1: Na₂SO₃ / methanol; H₂O

2: H₂ / Raney Nickel

3: PCl₅ / toluene

With phosphorus pentachloride; hydrogen; sodium sulfite; nickel; In methanol; water; toluene;

DOI:10.1016/0040-4039(93)85095-E

Reference yield:

benzaldehyde (100-52-7) → 2-Benzyl-3-(morpholine-4-sulfonyl)-propionic acid methyl ester (147794-61-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 90 percent / Dabco

2: 100 percent / HBr, H₂SO₄

3: Na₂SO₃ / methanol; H₂O

4: H₂ / Raney Nickel

5: PCl₅ / toluene

With 1,4-diaza-bicyclo[2.2.2]octane; phosphorus pentachloride; sulfuric acid; hydrogen bromide; hydrogen; sodium sulfite; nickel; In methanol; water; toluene;

DOI:10.1016/0040-4039(93)85095-E

Reference yield:

2-Carbomethoxy-3-phenylpropane-1-sulfonic acid Sodium salt → 2-Benzyl-3-(morpholine-4-sulfonyl)-propionic acid methyl ester (147794-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1: PCl₅ / toluene

With phosphorus pentachloride; In toluene;

DOI:10.1016/0040-4039(93)85095-E

upstream raw materials:

morpholine

methyl 2-benzyl-3-(chlorosulfonyl)propionate

benzaldehyde

(Z)-methyl 2-(bromomethyl)-3-phenylacrylate

Downstream raw materials:

(2S) 2-Benzyl-3-(1-methyl-piperazin-4-ylsulfonyl)propionic Acid