Technology Process of (4R)-(+)-2,3,4-trimethylcyclohex-2-enone
There total 8 articles about (4R)-(+)-2,3,4-trimethylcyclohex-2-enone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyllithium; 3-((-)-menthyloxy)-2,6-dimethylcyclohexen-2-one;
With
methyllithium;
In
tetrahydrofuran; diethyl ether;
at 0 ℃;
for 1h;
With
hydrogenchloride;
In
tetrahydrofuran; diethyl ether; water;
at 0 ℃;
for 0.166667h;
Further stages.;
DOI:10.1021/ol006561c
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
benzene;
for 12h;
Heating;
DOI:10.1021/jo035008g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: KOt-Bu / tetrahydrofuran; 2-methyl-propan-2-ol / 4 h
2.1: methyllithium / tetrahydrofuran; diethyl ether / 1 h / 0 °C
2.2: 100 percent / HCl / tetrahydrofuran; diethyl ether; H2O / 0.17 h / 0 °C
With
potassium tert-butylate; methyllithium;
In
tetrahydrofuran; diethyl ether; tert-butyl alcohol;
DOI:10.1021/ol006561c
