(3S,4R)-2,3,4-Trimethyl-3-(4-trimethylsilanyl-but-3-ynyl)-1-trimethylsilanyloxy-cyclohexene

Base Information

Chemical Name:(3S,4R)-2,3,4-Trimethyl-3-(4-trimethylsilanyl-but-3-ynyl)-1-trimethylsilanyloxy-cyclohexene
CAS No.:627460-71-3
Molecular Formula:C₁₉H₃₆OSi₂
Molecular Weight:336.665
Hs Code.:

Synonyms:(3S,4R)-2,3,4-Trimethyl-3-(4-trimethylsilanyl-but-3-ynyl)-1-trimethylsilanyloxy-cyclohexene

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Chemical Property of (3S,4R)-2,3,4-Trimethyl-3-(4-trimethylsilanyl-but-3-ynyl)-1-trimethylsilanyloxy-cyclohexene

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Technology Process of (3S,4R)-2,3,4-Trimethyl-3-(4-trimethylsilanyl-but-3-ynyl)-1-trimethylsilanyloxy-cyclohexene

There total 5 articles about (3S,4R)-2,3,4-Trimethyl-3-(4-trimethylsilanyl-but-3-ynyl)-1-trimethylsilanyloxy-cyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-77-4
chloro-trimethyl-silane

: 58435-00-0
1-chloro-5-trimethylsilyl-4-pentyne

: 307492-45-1
(4R)-(+)-2,3,4-trimethylcyclohex-2-enone

: 627460-71-3
(3S,4R)-2,3,4-Trimethyl-3-(4-trimethylsilanyl-but-3-ynyl)-1-trimethylsilanyloxy-cyclohexene

Guidance literature:: 1-chloro-5-trimethylsilyl-4-pentyne; With magnesium; ethylene dibromide; In tetrahydrofuran; for 2h; Heating;

chloro-trimethyl-silane; (4R)-(+)-2,3,4-trimethylcyclohex-2-enone; With N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; triethylamine; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/jo035008g

Reference yield:

: 89-82-7,90449-51-7
pulegone

: 627460-71-3
(3S,4R)-2,3,4-Trimethyl-3-(4-trimethylsilanyl-but-3-ynyl)-1-trimethylsilanyloxy-cyclohexene

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropylcyclohexylamine; n-BuLi / tetrahydrofuran / -78 - 20 °C

2.1: 16.1 g / tetrahydrofuran / 1 h / -78 °C

3.1: O₃ / CH₂Cl₂ / -78 °C

3.2: 76 percent / (CH₃)2S / CH₂Cl₂ / 20 °C

4.1: 68 percent / p-TSA*7H₂O / benzene / 12 h / Heating

5.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 2 h / Heating

5.2: CuI; HMPA; Et₃N / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; N-cyclohexylisopropylamine; toluene-4-sulfonic acid; ozone; magnesium; ethylene dibromide; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/jo035008g

Reference yield:

: 149403-82-7
(5R,6S)-2-(1-methylethylidene)-5,6-dimethylcyclohexanone

: 627460-71-3
(3S,4R)-2,3,4-Trimethyl-3-(4-trimethylsilanyl-but-3-ynyl)-1-trimethylsilanyloxy-cyclohexene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 16.1 g / tetrahydrofuran / 1 h / -78 °C

2.1: O₃ / CH₂Cl₂ / -78 °C

2.2: 76 percent / (CH₃)2S / CH₂Cl₂ / 20 °C

3.1: 68 percent / p-TSA*7H₂O / benzene / 12 h / Heating

4.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 2 h / Heating

4.2: CuI; HMPA; Et₃N / tetrahydrofuran / -78 - 20 °C

With toluene-4-sulfonic acid; ozone; magnesium; ethylene dibromide; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/jo035008g