5-[2-(2-fluoro-3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

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Chemical Name:5-[2-(2-fluoro-3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine
CAS No.:1453207-91-4
Molecular Formula:C₃₁H₄₁FN₆O₃
Molecular Weight:564.703
Hs Code.:

Synonyms:5-[2-(2-fluoro-3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

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Chemical Property of 5-[2-(2-fluoro-3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

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Technology Process of 5-[2-(2-fluoro-3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

There total 4 articles about 5-[2-(2-fluoro-3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1453207-90-3
5-[(2-fluoro-3,5-dimethoxyphenyl)ethynyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

: 1453207-91-4
5-[2-(2-fluoro-3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

Guidance literature:: With sodium acetate; toluene-4-sulfonic acid hydrazide; In 1,2-dimethoxyethane; at 110 ℃;
DOI:10.1016/j.bmc.2021.116019

Reference yield:

: 171290-52-1
1-Ethynyl-3,5-dimethoxy-benzene

: 1453207-91-4
5-[2-(2-fluoro-3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: Selectfluor / acetonitrile / 96 h / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 1 h / 80 °C / Inert atmosphere

3: sodium acetate; toluene-4-sulfonic acid hydrazide / 1,2-dimethoxyethane / 110 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium acetate; Selectfluor; N-ethyl-N,N-diisopropylamine; toluene-4-sulfonic acid hydrazide; In 1,2-dimethoxyethane; acetonitrile; 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmc.2021.116019

Reference yield:

: 1254058-34-8
3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline

: 1453207-91-4
5-[2-(2-fluoro-3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: methanesulfonic acid / 3 h / 130 °C / Microwave irradiation

2: N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 1 h / 80 °C / Inert atmosphere

3: sodium acetate; toluene-4-sulfonic acid hydrazide / 1,2-dimethoxyethane / 110 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonic acid; sodium acetate; N-ethyl-N,N-diisopropylamine; toluene-4-sulfonic acid hydrazide; In 1,2-dimethoxyethane; 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmc.2021.116019