(1R,5S,7S,8R)-8-Bromo-7,8-bis-(3,4-dimethoxy-phenyl)-10-oxa-1-azonia-tricyclo[5.2.1.0^1,5]decane; bromide

Base Information

• Chemical Name: (1R,5S,7S,8R)-8-Bromo-7,8-bis-(3,4-dimethoxy-phenyl)-10-oxa-1-azonia-tricyclo[5.2.1.0^1,5]decane; bromide
• CAS No.: 73786-27-3
• Molecular Formula: Br*C₂₄H₂₉BrNO₅
• Molecular Weight: 571.306

Synonyms:(1R,5S,7S,8R)-8-Bromo-7,8-bis-(3,4-dimethoxy-phenyl)-10-oxa-1-azonia-tricyclo[5.2.1.0^1,5]decane; bromide

Chemical Property of (1R,5S,7S,8R)-8-Bromo-7,8-bis-(3,4-dimethoxy-phenyl)-10-oxa-1-azonia-tricyclo[5.2.1.0^1,5]decane; bromide

Chemical Property:

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Technology Process of (1R,5S,7S,8R)-8-Bromo-7,8-bis-(3,4-dimethoxy-phenyl)-10-oxa-1-azonia-tricyclo[5.2.1.0^1,5]decane; bromide

There total 5 articles about (1R,5S,7S,8R)-8-Bromo-7,8-bis-(3,4-dimethoxy-phenyl)-10-oxa-1-azonia-tricyclo[5.2.1.0^1,5]decane; bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

isoxazolidine (73786-26-2,73786-29-5) → (1R,5S,7S,8R)-8-Bromo-7,8-bis-(3,4-dimethoxy-phenyl)-10-oxa-1-azonia-tricyclo[5.2.1.01,5]decane; bromide (73786-27-3)

Guidance literature:

With bromine; In chloroform; Ambient temperature;

DOI:10.1246/cl.1980.383

Reference yield:

2,3-bis(3,4-dimethoxyphenyl)butane-2,3-diol (94762-80-8) → (1R,5S,7S,8R)-8-Bromo-7,8-bis-(3,4-dimethoxy-phenyl)-10-oxa-1-azonia-tricyclo[5.2.1.01,5]decane; bromide (73786-27-3)

Guidance literature:

Multi-step reaction with 3 steps

1: POCl₃ / pyridine

2: 42 percent / toluene / 2 h / Heating

3: 88 percent / bromine / CHCl₃ / Ambient temperature

With bromine; trichlorophosphate; In pyridine; chloroform; toluene;

DOI:10.1246/cl.1980.383

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → (1R,5S,7S,8R)-8-Bromo-7,8-bis-(3,4-dimethoxy-phenyl)-10-oxa-1-azonia-tricyclo[5.2.1.01,5]decane; bromide (73786-27-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 2) CrO₃, H₂SO₄

2: Al, Hg

3: POCl₃ / pyridine

4: 42 percent / toluene / 2 h / Heating

5: 88 percent / bromine / CHCl₃ / Ambient temperature

With chromium(VI) oxide; aluminum amalgam; sulfuric acid; bromine; aluminium; mercury; trichlorophosphate; In pyridine; chloroform; toluene;

DOI:10.1246/cl.1980.383

upstream raw materials:

isoxazolidine

2,3-bis(3,4-dimethoxyphenyl)butane-2,3-diol

3,4-dimethoxy-benzaldehyde

2,3-bis(3,4-dimethoxyphenyl)-1,3-butadiene

Downstream raw materials:

4,4'-(ethene-1,1-diyl)bis(1,2-dimethoxybenzene)

(1aR,2aR,6aR)-1a,6a-Bis-(3,4-dimethoxy-phenyl)-octahydro-1-oxa-5a-aza-cyclopropa[f]indene

isoxazolidine

(R)-2,3-Bis-(3,4-dimethoxy-phenyl)-1-(R)-pyrrolidin-2-yl-but-3-en-2-ol

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