[tris(tert-butyldimethylsilyloxymethyl)methyl]-6-(N-benzyloxycarbonylamino)hexanamide

Base Information

• Chemical Name: [tris(tert-butyldimethylsilyloxymethyl)methyl]-6-(N-benzyloxycarbonylamino)hexanamide
• CAS No.: 881665-16-3
• Molecular Formula: C₃₆H₇₀N₂O₆Si₃
• Molecular Weight: 711.218
• Mol file: 881665-16-3.mol

Synonyms:[tris(tert-butyldimethylsilyloxymethyl)methyl]-6-(N-benzyloxycarbonylamino)hexanamide

Chemical Property of [tris(tert-butyldimethylsilyloxymethyl)methyl]-6-(N-benzyloxycarbonylamino)hexanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [tris(tert-butyldimethylsilyloxymethyl)methyl]-6-(N-benzyloxycarbonylamino)hexanamide

There total 4 articles about [tris(tert-butyldimethylsilyloxymethyl)methyl]-6-(N-benzyloxycarbonylamino)hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

6-(benzyloxycarbonylamino)hexanoic acid (1947-00-8) + 6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2,3,3,9,9,10,10-octamethyl-4,8-dioxa-3,9-disilaundecan-6-amine (102522-47-4) → [tris(tert-butyldimethylsilyloxymethyl)methyl]-6-(N-benzyloxycarbonylamino)hexanamide (881665-16-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1039/b509668e

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → [tris(tert-butyldimethylsilyloxymethyl)methyl]-6-(N-benzyloxycarbonylamino)hexanamide (881665-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / imidazole / dimethylformamide / 4 h / 20 °C

2: 47 percent / DCC / CH₂Cl₂ / 20 °C

With 1H-imidazole; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/b509668e

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → [tris(tert-butyldimethylsilyloxymethyl)methyl]-6-(N-benzyloxycarbonylamino)hexanamide (881665-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NaOH / H₂O / 1 h / 20 °C / pH 10

2: 47 percent / DCC / CH₂Cl₂ / 20 °C

With sodium hydroxide; dicyclohexyl-carbodiimide; In dichloromethane; water;

DOI:10.1039/b509668e

upstream raw materials:

6-(benzyloxycarbonylamino)hexanoic acid

6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2,3,3,9,9,10,10-octamethyl-4,8-dioxa-3,9-disilaundecan-6-amine

tert-butyldimethylsilyl chloride

benzyl chloroformate