(5-bromo-1-benzofuran-2-yl)[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]methanone

Base Information

Chemical Name:(5-bromo-1-benzofuran-2-yl)[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]methanone
CAS No.:344900-02-3
Molecular Formula:C₂₀H₁₄BrNO₃
Molecular Weight:396.24
Hs Code.:

Synonyms:(5-bromo-1-benzofuran-2-yl)[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]methanone

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Chemical Property of (5-bromo-1-benzofuran-2-yl)[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]methanone

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Technology Process of (5-bromo-1-benzofuran-2-yl)[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]methanone

There total 1 articles about (5-bromo-1-benzofuran-2-yl)[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 2-bromo-1-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]-1-ethanone

: 1761-61-1
5-bromosalicyclaldehyde

: 344900-02-3
(5-bromo-1-benzofuran-2-yl)[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]methanone

Guidance literature:: 5-bromosalicyclaldehyde; With sodium methylate; In methanol; ethanol; for 0.333333h;

2-bromo-1-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]-1-ethanone; In methanol; ethanol; for 12h; Heating;
DOI:10.1016/S0223-5234(00)01191-0

Reference yield:

: 344900-02-3
(5-bromo-1-benzofuran-2-yl)[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]methanone

: 141820-33-9
(5-Bromo-benzofuran-2-yl)-(5-methyl-2-p-tolyl-oxazol-4-yl)-methanol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; for 1h; Ambient temperature;
DOI:10.1021/jm00109a003

Reference yield:

: 344900-02-3
(5-bromo-1-benzofuran-2-yl)[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]methanone

: 132646-58-3
5-[2-(5-Methyl-2-p-tolyl-oxazol-4-ylmethyl)-benzofuran-5-ylmethyl]-oxazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 7 steps

1: NaBH₄ / tetrahydrofuran; methanol / 1 h / Ambient temperature

2: CF₃COOH, triethylsilane / 1 h / 0 °C

3: dimethylformamide / 18 h / 150 °C

4: Ni-Al alloy, 70percent aq. HCOOH / 2 h / Heating

5: anhyd. sodium acetate / 1.5 h / 120 °C / 0.1 Torr

6: m-chloroperbenzoic acid / dimethylformamide / 2.5 h / Ambient temperature

7: H₂ / 10percent Pd/C / tetrahydrofuran / 2068.6 Torr / Ambient temperature

With triethylsilane; sodium tetrahydroborate; formic acid; aluminum nickel; hydrogen; sodium acetate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00109a003