Technology Process of 1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridine-2-ylboronic acid
There total 4 articles about 1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridine-2-ylboronic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: NaH / tetrahydrofuran / 0.5 h / 20 °C
1.2: 84 percent / tetrahydrofuran / 20 °C
2.1: N,N,N',N'-tetramethylethylenediamine; LDA / tetrahydrofuran; heptane; ethylbenzene / 0.5 h / -20 °C
2.2: tetrahydrofuran; hexane; ethylbenzene / 5 h / -20 °C
3.1: 165 mg / aq. HCl
With
hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; ethylbenzene;
DOI:10.1055/s-2005-916028
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N,N,N',N'-tetramethylethylenediamine; LDA / tetrahydrofuran; heptane; ethylbenzene / 0.5 h / -20 °C
1.2: tetrahydrofuran; hexane; ethylbenzene / 5 h / -20 °C
2.1: 165 mg / aq. HCl
With
hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; ethylbenzene;
DOI:10.1055/s-2005-916028
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: NaH / tetrahydrofuran / 0.5 h / 20 °C
1.2: 84 percent / tetrahydrofuran / 20 °C
2.1: N,N,N',N'-tetramethylethylenediamine; LDA / tetrahydrofuran; heptane; ethylbenzene / 0.5 h / -20 °C
2.2: tetrahydrofuran; hexane; ethylbenzene / 5 h / -20 °C
3.1: 165 mg / aq. HCl
With
hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; ethylbenzene;
DOI:10.1055/s-2005-916028
