N9-(3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-adenine

Base Information

• Chemical Name: N9-(3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-adenine
• CAS No.: 161821-96-1
• Molecular Formula: C₁₉H₂₂N₅O₇P
• Molecular Weight: 463.387

Synonyms:N9-(3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-adenine

Chemical Property of N9-(3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-adenine

Chemical Property:

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Technology Process of N9-(3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-adenine

There total 3 articles about N9-(3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N9-(2-O-acetyl-3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-adenine (161821-90-5) → N9-(3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-adenine (161821-96-1)

Guidance literature:

With hydrazine hydrate; In pyridine; acetic acid; for 24h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85564-2

Reference yield:

adenine (66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9) → N9-(3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-adenine (161821-96-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 28 percent / SnCl₄ / acetonitrile / 120 h / Ambient temperature

2: 67 percent / H₂NNH₂*H₂O / acetic acid; pyridine / 24 h / Ambient temperature

With tin(IV) chloride; hydrazine hydrate; In pyridine; acetic acid; acetonitrile;

DOI:10.1016/S0040-4020(01)85564-2

Reference yield:

1,2-di-O-acetyl-3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-α-D-ribofuranose (161822-02-2) → N9-(3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-adenine (161821-96-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 28 percent / SnCl₄ / acetonitrile / 120 h / Ambient temperature

2: 67 percent / H₂NNH₂*H₂O / acetic acid; pyridine / 24 h / Ambient temperature

With tin(IV) chloride; hydrazine hydrate; In pyridine; acetic acid; acetonitrile;

DOI:10.1016/S0040-4020(01)85564-2

upstream raw materials:

N9-(2-O-acetyl-3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-adenine

adenine

1,2-di-O-acetyl-3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-α-D-ribofuranose

Downstream raw materials:

N9-(2,3-dideoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-adenine

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