5-[(2-Fluorophenoxy)methyl]-1,3,4-thiadiazol-2-amine

Base Information

Chemical Name:5-[(2-Fluorophenoxy)methyl]-1,3,4-thiadiazol-2-amine
CAS No.:247128-21-8
Molecular Formula:C₉H₈FN₃OS
Molecular Weight:225.246
Hs Code.:
DSSTox Substance ID:DTXSID301218211

Synonyms:5-[(2-fluorophenoxy)methyl]-1,3,4-thiadiazol-2-amine;247128-21-8;CBMicro_022487;Cambridge id 5489332;Oprea1_372722;Oprea1_846074;SCHEMBL3736372;DTXSID301218211;CCG-9450;MFCD01008691;STK073980;AKOS000545062;BIM-0022419.P001;EN300-4341832;SR-01000210850;SR-01000210850-1;Z1415898337

Suppliers and Price of 5-[(2-Fluorophenoxy)methyl]-1,3,4-thiadiazol-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[(2-Fluorophenoxy)methyl]-1,3,4-thiadiazol-2-amine

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:225.03721122
Heavy Atom Count:15
Complexity:210

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C(=C1)OCC2=NN=C(S2)N)F

Technology Process of 5-[(2-Fluorophenoxy)methyl]-1,3,4-thiadiazol-2-amine

There total 5 articles about 5-[(2-Fluorophenoxy)methyl]-1,3,4-thiadiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1052694-72-0
2-{[(2-fluorophenyl)oxy]acetyl}hydrazinecarbonylthioamide

: 247128-21-8
5-{[(2-fluorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-amine

Guidance literature:: With phosphoric acid; at 120 ℃; for 2h;
DOI:10.1016/j.bmc.2010.11.034

Reference yield:

: 367-12-4
2-fluorophenol

: 247128-21-8
5-{[(2-fluorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 8 h / Reflux

2: hydrazine hydrate / methanol / 1 h / 20 °C

3: ethanol / 4 h / Reflux

4: phosphoric acid / 2 h / 120 °C

With ethanol; phosphoric acid; potassium carbonate; hydrazine hydrate; In methanol; acetone;
DOI:10.1016/j.bmc.2010.11.034

Reference yield:

: 2248-56-8
ethyl 2-(4-fluorophenoxy)acetate

: 247128-21-8
5-{[(2-fluorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / methanol / 1 h / 20 °C

2: ethanol / 4 h / Reflux

3: phosphoric acid / 2 h / 120 °C

With ethanol; phosphoric acid; hydrazine hydrate; In methanol;
DOI:10.1016/j.bmc.2010.11.034