P¹,P²-dithymidine 5'-pyrophosphate

Base Information

• Chemical Name: P¹,P²-dithymidine 5'-pyrophosphate
• CAS No.: 4353-66-6
• Molecular Formula: C₂₀H₂₈N₄O₁₅P₂
• Molecular Weight: 626.408
• Mol file: 4353-66-6.mol

Synonyms:P¹,P²-dithymidine 5'-pyrophosphate

Chemical Property of P¹,P²-dithymidine 5'-pyrophosphate

Chemical Property:

Purity/Quality:

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Technology Process of P¹,P²-dithymidine 5'-pyrophosphate

There total 4 articles about P¹,P²-dithymidine 5'-pyrophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

morpholine (110-91-8,99108-56-2) + thymidine 5'-phosphate bis(tributylammonium) salt → thymidine 5'-phosphate (365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1) + P1,P2-dithymidine 5'-pyrophosphate (4353-66-6) + thymidine 5'-monophosphate morpholidate (23583-44-0)

Guidance literature:

thymidine 5'-phosphate bis(tributylammonium) salt; With tributyl-amine; trichloroacetic acid anhydride; In N,N-dimethyl-formamide; at 22 - 25 ℃;

morpholine; With ammonium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1023/A:1022282503476

Reference yield:

morpholine (110-91-8,99108-56-2) + thymidine 5'-phosphate bis(tributylammonium) salt + trichloroacetic acid anhydride (4124-31-6) → thymidine 5'-phosphate (365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1) + P1,P2-dithymidine 5'-pyrophosphate (4353-66-6) + thymidine 5'-monophosphate morpholidate (23583-44-0) + Trichloro-acetic acid (2R,3S,5R)-2-(hydroxy-morpholin-4-yl-phosphinoyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:

thymidine 5'-phosphate bis(tributylammonium) salt; trichloroacetic acid anhydride; With tributyl-amine; In N,N-dimethyl-formamide; at 22 - 25 ℃;

morpholine; In N,N-dimethyl-formamide; Further byproducts given; Heating;

DOI:10.1023/A:1022282503476

Reference yield:

tribromoacetyl bromide (10588-31-5) + thymidine 5'-phosphate (365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1) → P1,P2-dithymidine 5'-pyrophosphate (4353-66-6) + C12H14Br3N2O9P + Tribromo-acetic acid (2R,3S,5R)-2-[hydroxy-(2,2,2-tribromo-acetoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester + C24H26Br6N4O17P2

Guidance literature:

With tributyl-amine; In acetonitrile; at 22 - 25 ℃; Further byproducts given;

DOI:10.1023/A:1022282503476

upstream raw materials:

morpholine

trichloroacetic acid anhydride

tribromoacetyl bromide

thymidine 5'-phosphate

Refernces