trans-((2S,3R)-3-(2,8-bis(trifluoromethyl)quinolin-4-yl)oxiran-2-yl)(phenyl)methanone

Base Information

Chemical Name:trans-((2S,3R)-3-(2,8-bis(trifluoromethyl)quinolin-4-yl)oxiran-2-yl)(phenyl)methanone
CAS No.:1309854-82-7
Molecular Formula:C₂₀H₁₁F₆NO₂
Molecular Weight:411.303
Hs Code.:

Synonyms:trans-((2S,3R)-3-(2,8-bis(trifluoromethyl)quinolin-4-yl)oxiran-2-yl)(phenyl)methanone

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Chemical Property of trans-((2S,3R)-3-(2,8-bis(trifluoromethyl)quinolin-4-yl)oxiran-2-yl)(phenyl)methanone

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Technology Process of trans-((2S,3R)-3-(2,8-bis(trifluoromethyl)quinolin-4-yl)oxiran-2-yl)(phenyl)methanone

There total 4 articles about trans-((2S,3R)-3-(2,8-bis(trifluoromethyl)quinolin-4-yl)oxiran-2-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: C₃₀H₂₅F₆N₃O₃

: 1309854-82-7
trans-((2S,3R)-3-(2,8-bis(trifluoromethyl)quinolin-4-yl)oxiran-2-yl)(phenyl)methanone

Guidance literature:: With toluene-4-sulfonic acid; In pentan-3-one; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/ol2010193

Reference yield:

: C₁₈H₂₁ClN₂O₂

: 1309854-82-7
trans-((2S,3R)-3-(2,8-bis(trifluoromethyl)quinolin-4-yl)oxiran-2-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.75 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / pentan-3-one / 18 h / 20 °C / Inert atmosphere

With n-butyllithium; toluene-4-sulfonic acid; diisopropylamine; In tetrahydrofuran; hexane; pentan-3-one; 1.1: Darzens condensation / 1.2: Darzens condensation;
DOI:10.1021/ol2010193

Reference yield:

: 35853-45-3
(2,8-bis-trifluoromethyl)-4-bromoquinoline

: 1309854-82-7
trans-((2S,3R)-3-(2,8-bis(trifluoromethyl)quinolin-4-yl)oxiran-2-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / -78 °C / Inert atmosphere

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.75 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid / pentan-3-one / 18 h / 20 °C / Inert atmosphere

With n-butyllithium; toluene-4-sulfonic acid; diisopropylamine; In tetrahydrofuran; hexane; pentan-3-one; 2.1: Darzens condensation / 2.2: Darzens condensation;
DOI:10.1021/ol2010193