N-(2-chloro-6-methylphenyl)-2-[2-(piperidin-1-yl)acetamido]-5-thiazolecarboxamide

Base Information

Chemical Name:N-(2-chloro-6-methylphenyl)-2-[2-(piperidin-1-yl)acetamido]-5-thiazolecarboxamide
CAS No.:1323138-55-1
Molecular Formula:C₁₈H₂₁ClN₄O₂S
Molecular Weight:392.909
Hs Code.:

Synonyms:N-(2-chloro-6-methylphenyl)-2-[2-(piperidin-1-yl)acetamido]-5-thiazolecarboxamide

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Chemical Property of N-(2-chloro-6-methylphenyl)-2-[2-(piperidin-1-yl)acetamido]-5-thiazolecarboxamide

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Technology Process of N-(2-chloro-6-methylphenyl)-2-[2-(piperidin-1-yl)acetamido]-5-thiazolecarboxamide

There total 6 articles about N-(2-chloro-6-methylphenyl)-2-[2-(piperidin-1-yl)acetamido]-5-thiazolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.7%

: 110-89-4
piperidine

: 1323138-80-2
N-(2-chloro-6-methylphenyl)-2-(2-chloroacetamido)-5-thiazolecarboxamide

: 1323138-55-1
N-(2-chloro-6-methylphenyl)-2-[2-(piperidin-1-yl)acetamido]-5-thiazolecarboxamide

Guidance literature:: With potassium carbonate; potassium iodide; In tetrahydrofuran; at 60 ℃; for 1h;
DOI:10.1002/ardp.201000281

Reference yield:

: 302964-24-5
2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide

: 1323138-55-1
N-(2-chloro-6-methylphenyl)-2-[2-(piperidin-1-yl)acetamido]-5-thiazolecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: acetone / 6 h / Reflux

With triethylamine; In dichloromethane; acetone;
DOI:10.3184/174751911X13099483874341

Reference yield:

: C₁₁H₁₁BrClN₃OS

: 1323138-55-1
N-(2-chloro-6-methylphenyl)-2-[2-(piperidin-1-yl)acetamido]-5-thiazolecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: acetone / 6 h / Reflux

With triethylamine; In dichloromethane; acetone;
DOI:10.3184/174751911X13099483874341