[(2-Amino-4-bromo-benzoyl)-tert-butyl-amino]-acetic acid methyl ester

Base Information

• Chemical Name: [(2-Amino-4-bromo-benzoyl)-tert-butyl-amino]-acetic acid methyl ester
• CAS No.: 1027990-59-5
• Molecular Formula: C₁₄H₁₉BrN₂O₃
• Molecular Weight: 343.22
• Mol file: 1027990-59-5.mol

Synonyms:[(2-Amino-4-bromo-benzoyl)-tert-butyl-amino]-acetic acid methyl ester

Chemical Property of [(2-Amino-4-bromo-benzoyl)-tert-butyl-amino]-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(2-Amino-4-bromo-benzoyl)-tert-butyl-amino]-acetic acid methyl ester

There total 4 articles about [(2-Amino-4-bromo-benzoyl)-tert-butyl-amino]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyl 4-bromo-β-tert-butyl-2-nitrohippurate (171819-63-9) → [(2-Amino-4-bromo-benzoyl)-tert-butyl-amino]-acetic acid methyl ester (1027990-59-5)

Guidance literature:

With hydrogen; platinum on activated charcoal; In tetrahydrofuran; ethanol; for 28h; under 2585.7 Torr;

DOI:10.1021/jo00123a016

Reference yield:

N-(t-butyl)glycine methyl ester (53386-65-5) → [(2-Amino-4-bromo-benzoyl)-tert-butyl-amino]-acetic acid methyl ester (1027990-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / Et₃N / tetrahydrofuran; toluene / 16 h / Ambient temperature

2: H₂ / 5percent Pt/C / tetrahydrofuran; ethanol / 28 h / 2585.7 Torr

With hydrogen; triethylamine; platinum on activated charcoal; In tetrahydrofuran; ethanol; toluene;

DOI:10.1021/jo00123a016

Reference yield:

4-bromo-2-nitrobenzoic acid (99277-71-1) → [(2-Amino-4-bromo-benzoyl)-tert-butyl-amino]-acetic acid methyl ester (1027990-59-5)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂, DMF / toluene / 16 h / 80 °C

2: 60 percent / Et₃N / tetrahydrofuran; toluene / 16 h / Ambient temperature

3: H₂ / 5percent Pt/C / tetrahydrofuran; ethanol / 28 h / 2585.7 Torr

With thionyl chloride; hydrogen; triethylamine; N,N-dimethyl-formamide; platinum on activated charcoal; In tetrahydrofuran; ethanol; toluene;

DOI:10.1021/jo00123a016

upstream raw materials:

Methyl 4-bromo-β-tert-butyl-2-nitrohippurate

N-(t-butyl)glycine methyl ester

4-bromo-2-nitrobenzoic acid

4-bromo-2-nitro-benzoyl chloride