tert-butyl (+/-)-3-(3-(2-cyclopentyl-2-(4-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)acetamido)-2-methylphenyl)propanoate

Base Information

Chemical Name:tert-butyl (+/-)-3-(3-(2-cyclopentyl-2-(4-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)acetamido)-2-methylphenyl)propanoate
CAS No.:1192040-42-8
Molecular Formula:C₃₆H₄₀N₂O₅
Molecular Weight:580.724
Hs Code.:

Synonyms:tert-butyl (+/-)-3-(3-(2-cyclopentyl-2-(4-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)acetamido)-2-methylphenyl)propanoate

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Chemical Property of tert-butyl (+/-)-3-(3-(2-cyclopentyl-2-(4-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)acetamido)-2-methylphenyl)propanoate

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Technology Process of tert-butyl (+/-)-3-(3-(2-cyclopentyl-2-(4-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)acetamido)-2-methylphenyl)propanoate

There total 7 articles about tert-butyl (+/-)-3-(3-(2-cyclopentyl-2-(4-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)acetamido)-2-methylphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1191413-21-4
tert-butyl 3-(3-amino-2-methylphenyl)propanoate

: 1192040-41-7
(+/-)-2-cyclopentyl-2-(4-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)acetic acid

: 1192040-42-8
tert-butyl (+/-)-3-(3-(2-cyclopentyl-2-(4-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)acetamido)-2-methylphenyl)propanoate

Guidance literature:: (+/-)-2-cyclopentyl-2-(4-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)acetic acid; With pyridine; N-[(6-chlorobenzotriazol-1-yl)oxy-(dimethylamino)methylene]-dimethyl-ammonium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

tert-butyl 3-(3-amino-2-methylphenyl)propanoate; In N,N-dimethyl-formamide;

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 1192040-42-8
tert-butyl (+/-)-3-(3-(2-cyclopentyl-2-(4-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)acetamido)-2-methylphenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 36 h / 125 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / ethanol / 18 h / 20 °C

3: pyridine; N-[(6-chlorobenzotriazol-1-yl)oxy-(dimethylamino)methylene]-dimethyl-ammonium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / 20 °C

With pyridine; N-[(6-chlorobenzotriazol-1-yl)oxy-(dimethylamino)methylene]-dimethyl-ammonium tetrafluoroborate; hydrogen; triethylamine; palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine; In ethanol; N,N-dimethyl-formamide;

Reference yield:

2-bromo-6-nitrotoluene: 55289-35-5
2-bromo-6-nitrotoluene

: 1192040-42-8
tert-butyl (+/-)-3-(3-(2-cyclopentyl-2-(4-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)acetamido)-2-methylphenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 36 h / 125 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / ethanol / 18 h / 20 °C

3: pyridine; N-[(6-chlorobenzotriazol-1-yl)oxy-(dimethylamino)methylene]-dimethyl-ammonium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / 20 °C

With pyridine; N-[(6-chlorobenzotriazol-1-yl)oxy-(dimethylamino)methylene]-dimethyl-ammonium tetrafluoroborate; hydrogen; triethylamine; palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine; In ethanol; N,N-dimethyl-formamide;