(4R)-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-(3-methyl-1,2,4-oxadiazol-5-yl)-6-(4-chloro-phenyl)

Base Information

Chemical Name:(4R)-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-(3-methyl-1,2,4-oxadiazol-5-yl)-6-(4-chloro-phenyl)
CAS No.:1407831-00-8
Molecular Formula:C₂₁H₁₉ClN₆O
Molecular Weight:406.874
Hs Code.:

Synonyms:(4R)-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-(3-methyl-1,2,4-oxadiazol-5-yl)-6-(4-chloro-phenyl)

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Chemical Property of (4R)-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-(3-methyl-1,2,4-oxadiazol-5-yl)-6-(4-chloro-phenyl)

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Technology Process of (4R)-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-(3-methyl-1,2,4-oxadiazol-5-yl)-6-(4-chloro-phenyl)

There total 10 articles about (4R)-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-(3-methyl-1,2,4-oxadiazol-5-yl)-6-(4-chloro-phenyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1407834-56-3
(4R)-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-(acetimidamidooxycarbonyl)-6-(4-chloro-phenyl)

: 1407831-00-8
(4R)-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-(3-methyl-1,2,4-oxadiazol-5-yl)-6-(4-chloro-phenyl)

Guidance literature:: With sodium acetate; In ethanol; water; at 86 ℃; for 5h;

Reference yield:

: 1407833-48-0
methyl 3-(5-bromo-2-nitrophenylamino)-2-methylpropanoate

: 1407831-00-8
(4R)-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-(3-methyl-1,2,4-oxadiazol-5-yl)-6-(4-chloro-phenyl)

Guidance literature:: Multi-step reaction with 10 steps

1.1: ammonium chloride; iron / ethanol; water / 2 h / 60 °C

2.1: sodium / methanol / 0 - 20 °C

3.1: Lawessons reagent / tetrahydrofuran / 12 h / 80 °C

4.1: butan-1-ol / 12 h / 130 °C

5.1: caesium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 12 h / 110 °C / Inert atmosphere

6.1: Daicel AD-H / 38 °C / Resolution of racemate

7.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / methanol / 12 h / 90 °C

8.1: sodium hydroxide / water; methanol / 5 h / 60 °C

8.2: pH 1

9.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 14 h / 20 °C

10.1: sodium acetate / ethanol; water / 5 h / 86 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; Lawessons reagent; 1,3-bis-(diphenylphosphino)propane; sodium acetate; sodium; iron; ammonium chloride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; butan-1-ol;

Reference yield:

: 1407830-61-8
(R)-8-bromo-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4Hbenzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine

: 1407831-00-8
(4R)-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-(3-methyl-1,2,4-oxadiazol-5-yl)-6-(4-chloro-phenyl)

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / methanol / 12 h / 90 °C

2.1: sodium hydroxide / water; methanol / 5 h / 60 °C

2.2: pH 1

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 14 h / 20 °C

4.1: sodium acetate / ethanol; water / 5 h / 86 °C

With 1,3-bis-(diphenylphosphino)propane; sodium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; palladium diacetate; In methanol; ethanol; dichloromethane; water;