4,5-bis(5-benzyloxypent-1-yn-1-yl)-1,2-phenylene Bis(pent-4-yn-1-ol-5-yl) benzoate ester

Base Information

Chemical Name:4,5-bis(5-benzyloxypent-1-yn-1-yl)-1,2-phenylene Bis(pent-4-yn-1-ol-5-yl) benzoate ester
CAS No.:1378950-85-6
Molecular Formula:C₅₄H₅₀O₆
Molecular Weight:794.987
Hs Code.:

Synonyms:4,5-bis(5-benzyloxypent-1-yn-1-yl)-1,2-phenylene Bis(pent-4-yn-1-ol-5-yl) benzoate ester

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Chemical Property of 4,5-bis(5-benzyloxypent-1-yn-1-yl)-1,2-phenylene Bis(pent-4-yn-1-ol-5-yl) benzoate ester

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Technology Process of 4,5-bis(5-benzyloxypent-1-yn-1-yl)-1,2-phenylene Bis(pent-4-yn-1-ol-5-yl) benzoate ester

There total 9 articles about 4,5-bis(5-benzyloxypent-1-yn-1-yl)-1,2-phenylene Bis(pent-4-yn-1-ol-5-yl) benzoate ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1378950-63-0
4,5-bis(5-benzyloxypent-1-yn-1-yl)-1,2-phenylene Bis(trifluoromethanesulfonate)

: 100330-28-7
pent-4-yn-1-yl benzoate

: 1378950-85-6
4,5-bis(5-benzyloxypent-1-yn-1-yl)-1,2-phenylene Bis(pent-4-yn-1-ol-5-yl) benzoate ester

Guidance literature:: With tetra-(n-butyl)ammonium iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; at 70 ℃; for 5.5h; Inert atmosphere;

Reference yield: 64.0%

: 4,5-bis(5-benzyloxypent-1-ynyl)-1,2-phenylene bis(trifluoromethane)sulfonate

: 100330-28-7
pent-4-yn-1-yl benzoate

: 1378950-85-6
4,5-bis(5-benzyloxypent-1-yn-1-yl)-1,2-phenylene Bis(pent-4-yn-1-ol-5-yl) benzoate ester

Guidance literature:: 4,5-bis(5-benzyloxypent-1-ynyl)-1,2-phenylene bis(trifluoromethane)sulfonate; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetra-(n-butyl)ammonium iodide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

pent-4-yn-1-yl benzoate; In N,N-dimethyl-formamide; at 70 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201200079

Reference yield:

: 1378950-54-9
4,5-diiodo-1,2-phenylene bis(trifluoromethanesulfonate)

: 1378950-85-6
4,5-bis(5-benzyloxypent-1-yn-1-yl)-1,2-phenylene Bis(pent-4-yn-1-ol-5-yl) benzoate ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; tetra-(n-butyl)ammonium iodide; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.2: 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetra-(n-butyl)ammonium iodide; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Sonogashira coupling / 2.1: Sonogashira coupling / 2.2: Sonogashira coupling;
DOI:10.1002/ejoc.201200079