Technology Process of 2-(4-Methoxy-phenyl)-3-oxo-succinic acid dimethyl ester
There total 1 articles about 2-(4-Methoxy-phenyl)-3-oxo-succinic acid dimethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
benzene;
for 108h;
Ambient temperature;
DOI:10.1021/jo01297a049
- Guidance literature:
-
Multi-step reaction with 7 steps
1: K2CO3 / H2O / 8.25 h / Ambient temperature
2: 82 percent / NaOH / tetrahydrofuran / 1.) 13h RT, 2.) 3.5h 55 deg C
3: tetrahydrofuran / 16 h / Ambient temperature
4: Ph3P, NEt3 / acetonitrile / 0.5 h / Ambient temperature
5: 5.66 g / NaOH / H2O / 2.5 h / Heating
6: 77 percent / Bu4NI, methyl chloroformate / tetrahydrofuran / 8 h / Ambient temperature
7: 93 percent / KOH / H2O / 1 h / Heating
With
potassium hydroxide; sodium hydroxide; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; methyl chloroformate; triphenylphosphine;
In
tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jo01297a049
- Guidance literature:
-
Multi-step reaction with 8 steps
1: K2CO3 / H2O / 8.25 h / Ambient temperature
2: 82 percent / NaOH / tetrahydrofuran / 1.) 13h RT, 2.) 3.5h 55 deg C
3: tetrahydrofuran / 16 h / Ambient temperature
4: Ph3P, NEt3 / acetonitrile / 0.5 h / Ambient temperature
5: 5.66 g / NaOH / H2O / 2.5 h / Heating
6: 77 percent / Bu4NI, methyl chloroformate / tetrahydrofuran / 8 h / Ambient temperature
7: 93 percent / KOH / H2O / 1 h / Heating
8: 77 percent / LiAlH4 / tetrahydrofuran / 0.5 h / Ambient temperature
With
potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; methyl chloroformate; triphenylphosphine;
In
tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jo01297a049