{2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4]triazol-3-yl]-phenyl}-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

Base Information

Chemical Name:{2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4]triazol-3-yl]-phenyl}-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone
CAS No.:220603-26-9
Molecular Formula:C₃₀H₂₅ClN₆O₂
Molecular Weight:537.02
Hs Code.:

Synonyms:{2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4]triazol-3-yl]-phenyl}-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

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Chemical Property of {2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4]triazol-3-yl]-phenyl}-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

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Technology Process of {2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4]triazol-3-yl]-phenyl}-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

There total 15 articles about {2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4]triazol-3-yl]-phenyl}-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 220603-25-8
2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4] triazol-3-yl]-benzoyl chloride

: 16287-36-8
6,11-dihydro-5H-pyrido{2,3-b][1,5]benzodiazepine

: 220603-26-9
{2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4]triazol-3-yl]-phenyl}-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

Guidance literature:: With potassium carbonate; In N-methyl-acetamide; dichloromethane;

Reference yield: 38.0%

: 220603-26-9
{2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4]triazol-3-yl]-phenyl}-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

Guidance literature:

Reference yield:

: 98592-34-8
2-chloro-4-cyano benzoic acid methyl ester

: 220603-26-9
{2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4]triazol-3-yl]-phenyl}-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / aq. H₂O₂; K₂CO₃ / dimethylsulfoxide

2: 90 °C

3: NH₂NH₂; acetic acid

4: 66 percent / NaH

5: 81 percent / aq. NaOH / methanol

6: oxalyl chloride / dimethylformamide; CH₂Cl₂ / Heating

7: K₂CO₃ / dimethylformamide

With sodium hydroxide; oxalyl dichloride; dihydrogen peroxide; sodium hydride; potassium carbonate; acetic acid; hydrazine; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.10.107