2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4] triazol-3-yl]-benzoyl chloride

Base Information

Chemical Name:2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4] triazol-3-yl]-benzoyl chloride
CAS No.:220603-25-8
Molecular Formula:C₁₈H₁₅Cl₂N₃O₂
Molecular Weight:376.242
Hs Code.:

Synonyms:2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4] triazol-3-yl]-benzoyl chloride

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Chemical Property of 2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4] triazol-3-yl]-benzoyl chloride

Chemical Property:

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Technology Process of 2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4] triazol-3-yl]-benzoyl chloride

There total 9 articles about 2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4] triazol-3-yl]-benzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220603-24-7
2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4] triazol-3-yl]-benzoic acid

: 79-37-8
oxalyl dichloride

: 220603-25-8
2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4] triazol-3-yl]-benzoyl chloride

Guidance literature:: In N-methyl-acetamide; dichloromethane;

Reference yield:

: 98592-34-8
2-chloro-4-cyano benzoic acid methyl ester

: 220603-25-8
2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4] triazol-3-yl]-benzoyl chloride

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / aq. H₂O₂; K₂CO₃ / dimethylsulfoxide

2: 90 °C

3: NH₂NH₂; acetic acid

4: 66 percent / NaH

5: 81 percent / aq. NaOH / methanol

6: oxalyl chloride / dimethylformamide; CH₂Cl₂ / Heating

With sodium hydroxide; oxalyl dichloride; dihydrogen peroxide; sodium hydride; potassium carbonate; acetic acid; hydrazine; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.10.107

Reference yield:

: 220603-22-5
2-Chloro-4-(5-methyl-1H-[1,2,4] triazol-3-yl)-benzoic acid methyl ester

: 220603-25-8
2-Chloro-4-[1-(4-methoxy-benzyl)-5-methyl-1H-[1,2,4] triazol-3-yl]-benzoyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / NaH

2: 81 percent / aq. NaOH / methanol

3: oxalyl chloride / dimethylformamide; CH₂Cl₂ / Heating

With sodium hydroxide; oxalyl dichloride; sodium hydride; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.10.107