methyl 5-[2-(1-benzyl-1H-indol-3-yl)ethylamino]-1,3,4-oxadiazole-2-carboxylate

Base Information

Chemical Name:methyl 5-[2-(1-benzyl-1H-indol-3-yl)ethylamino]-1,3,4-oxadiazole-2-carboxylate
CAS No.:909707-95-5
Molecular Formula:C₂₁H₂₀N₄O₃
Molecular Weight:376.415
Hs Code.:

Synonyms:methyl 5-[2-(1-benzyl-1H-indol-3-yl)ethylamino]-1,3,4-oxadiazole-2-carboxylate

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Chemical Property of methyl 5-[2-(1-benzyl-1H-indol-3-yl)ethylamino]-1,3,4-oxadiazole-2-carboxylate

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Technology Process of methyl 5-[2-(1-benzyl-1H-indol-3-yl)ethylamino]-1,3,4-oxadiazole-2-carboxylate

There total 3 articles about methyl 5-[2-(1-benzyl-1H-indol-3-yl)ethylamino]-1,3,4-oxadiazole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 909707-94-4
methyl 2-{2-[2-(1-benzyl-1H-indol-3-yl)ethylcarbamoyl]hydrazino}-2-oxoacetate

: 909707-95-5
methyl 5-[2-(1-benzyl-1H-indol-3-yl)ethylamino]-1,3,4-oxadiazole-2-carboxylate

Guidance literature:: With triethylamine; p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/ja0612549

Reference yield:

: 909707-93-3
N-[2-(1-benzyl-1H-indol-3-yl)ethyl]-1H-imidazole-1-carboxamide

: 909707-95-5
methyl 5-[2-(1-benzyl-1H-indol-3-yl)ethylamino]-1,3,4-oxadiazole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / acetic acid / tetrahydrofuran / 16 h / Heating

2: 69 percent / TsCl; triethylamine / CH₂Cl₂ / 16 h / 20 °C

With acetic acid; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja0612549

Reference yield:

: 4307-98-6
N-benzyltryptamine

: 909707-95-5
methyl 5-[2-(1-benzyl-1H-indol-3-yl)ethylamino]-1,3,4-oxadiazole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / CH₂Cl₂; tetrahydrofuran / 20 °C

2: 82 percent / acetic acid / tetrahydrofuran / 16 h / Heating

3: 69 percent / TsCl; triethylamine / CH₂Cl₂ / 16 h / 20 °C

With acetic acid; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja0612549