3-hydroxy-4-(2-{2-[2-(4-phenyl-1,2,3-triazol-1-yl)ethoxy]ethoxy}ethoxy)butyronitrile

Base Information

Chemical Name:3-hydroxy-4-(2-{2-[2-(4-phenyl-1,2,3-triazol-1-yl)ethoxy]ethoxy}ethoxy)butyronitrile
CAS No.:1233223-66-9
Molecular Formula:C₁₈H₂₄N₄O₄
Molecular Weight:360.413
Hs Code.:

Synonyms:3-hydroxy-4-(2-{2-[2-(4-phenyl-1,2,3-triazol-1-yl)ethoxy]ethoxy}ethoxy)butyronitrile

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Chemical Property of 3-hydroxy-4-(2-{2-[2-(4-phenyl-1,2,3-triazol-1-yl)ethoxy]ethoxy}ethoxy)butyronitrile

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Technology Process of 3-hydroxy-4-(2-{2-[2-(4-phenyl-1,2,3-triazol-1-yl)ethoxy]ethoxy}ethoxy)butyronitrile

There total 4 articles about 3-hydroxy-4-(2-{2-[2-(4-phenyl-1,2,3-triazol-1-yl)ethoxy]ethoxy}ethoxy)butyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1233223-63-6
4-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}-3-hydroxybutyronitrile

: 536-74-3
phenylacetylene

: 1233223-66-9
3-hydroxy-4-(2-{2-[2-(4-phenyl-1,2,3-triazol-1-yl)ethoxy]ethoxy}ethoxy)butyronitrile

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In methanol; dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/bc900542f

Reference yield:

: 5197-62-6
2-[2-(chloroethoxy)ethoxy]ethanol

: 1233223-66-9
3-hydroxy-4-(2-{2-[2-(4-phenyl-1,2,3-triazol-1-yl)ethoxy]ethoxy}ethoxy)butyronitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide; sodium iodide / ethanol / 96 h / Reflux

2.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C

2.2: 16 h / 20 °C

3.1: ethanol; water / 16 h / 20 °C

4.1: copper(II) sulfate; sodium L-ascorbate / methanol; dichloromethane / 24 h / 20 °C

With sodium azide; sodium hydride; copper(II) sulfate; sodium L-ascorbate; sodium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1021/bc900542f

Reference yield:

: 1233223-64-7
2-{2-[2-(2-azidoethoxy)ethoxy]ethoxymethyl}oxirane

: 1233223-66-9
3-hydroxy-4-(2-{2-[2-(4-phenyl-1,2,3-triazol-1-yl)ethoxy]ethoxy}ethoxy)butyronitrile

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol; water / 16 h / 20 °C

2: copper(II) sulfate; sodium L-ascorbate / methanol; dichloromethane / 24 h / 20 °C

With copper(II) sulfate; sodium L-ascorbate; In methanol; ethanol; dichloromethane; water;
DOI:10.1021/bc900542f