Technology Process of 2,5-bis(2-thienyl)-1,4-divinylbenzene
There total 4 articles about 2,5-bis(2-thienyl)-1,4-divinylbenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at 0 ℃;
for 0.5h;
2,5-di(2-thienyl)-terephthalaldehyde;
In
tetrahydrofuran; hexane;
at 20 ℃;
for 24h;
Further stages.;
DOI:10.1021/ol071387e
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 66 percent / tetrakis(triphenylphosphine)palladium(0) / dimethylformamide / 72 h / 80 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C
2.2: 82 percent / tetrahydrofuran; hexane / 24 h / 20 °C
With
n-butyllithium;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; hexane; N,N-dimethyl-formamide;
1.1: Stille cross-coupling reaction / 2.1: Wittig olefination / 2.2: Wittig olefination;
DOI:10.1021/ol071387e
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Br2
2.1: (CH3O)2O; CH3COOH; H2SO4 / H2O
2.2: H2SO4; H2O / propan-2-ol
3.1: 66 percent / tetrakis(triphenylphosphine)palladium(0) / dimethylformamide / 72 h / 80 °C
4.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C
4.2: 82 percent / tetrahydrofuran; hexane / 24 h / 20 °C
With
n-butyllithium; (CH3O)2O; sulfuric acid; bromine; acetic acid;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; hexane; water; N,N-dimethyl-formamide;
3.1: Stille cross-coupling reaction / 4.1: Wittig olefination / 4.2: Wittig olefination;
DOI:10.1021/ol071387e
