4-(tert-butyl)-N-((4-((4-(dimethylamino)butyl)carbamoyl)phenyl)-carbamothioyl)benzamiide hydrochloride

Base Information

Chemical Name:4-(tert-butyl)-N-((4-((4-(dimethylamino)butyl)carbamoyl)phenyl)-carbamothioyl)benzamiide hydrochloride
CAS No.:1361226-35-8
Molecular Formula:C₂₅H₃₄N₄O₂S*ClH
Molecular Weight:491.097
Hs Code.:

Synonyms:4-(tert-butyl)-N-((4-((4-(dimethylamino)butyl)carbamoyl)phenyl)-carbamothioyl)benzamiide hydrochloride

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Chemical Property of 4-(tert-butyl)-N-((4-((4-(dimethylamino)butyl)carbamoyl)phenyl)-carbamothioyl)benzamiide hydrochloride

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Technology Process of 4-(tert-butyl)-N-((4-((4-(dimethylamino)butyl)carbamoyl)phenyl)-carbamothioyl)benzamiide hydrochloride

There total 7 articles about 4-(tert-butyl)-N-((4-((4-(dimethylamino)butyl)carbamoyl)phenyl)-carbamothioyl)benzamiide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1292534-00-9
4-amino-N-(4-(dimethylamino)butyl)benzamide

: 540-72-7
sodium thiocyanide

: 1710-98-1
p-tert-butyl benzoyl chloride

: 1361226-35-8
4-(tert-butyl)-N-((4-((4-(dimethylamino)butyl)carbamoyl)phenyl)-carbamothioyl)benzamiide hydrochloride

Guidance literature:: sodium thiocyanide; p-tert-butyl benzoyl chloride; In acetone; at 20 ℃; for 0.5h; Inert atmosphere;

4-amino-N-(4-(dimethylamino)butyl)benzamide; In acetone; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In diethyl ether; acetone;
DOI:10.1016/j.bmc.2012.01.001

Reference yield:

: 1361226-33-6
benzyl (4-((4-hydroxybutyl)carbamoyl)phenyl)carbamate

: 1361226-35-8
4-(tert-butyl)-N-((4-((4-(dimethylamino)butyl)carbamoyl)phenyl)-carbamothioyl)benzamiide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0 - 20 °C

2.1: dichloromethane; water / 18 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol

4.1: acetone / 0.5 h / 20 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

With carbon tetrabromide; palladium 10% on activated carbon; hydrogen; triphenylphosphine; In methanol; dichloromethane; water; acetone;
DOI:10.1016/j.bmc.2012.01.001

Reference yield:

: 1380098-27-0
C₁₉H₂₁BrN₂O₃

: 1361226-35-8
4-(tert-butyl)-N-((4-((4-(dimethylamino)butyl)carbamoyl)phenyl)-carbamothioyl)benzamiide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane; water / 18 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol

3.1: acetone / 0.5 h / 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; water; acetone;
DOI:10.1016/j.bmc.2012.01.001