1-oxo-1-((4'-(trifluoromethyl)biphenyl-2-yl)methyl)-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid

Base Information

Chemical Name:1-oxo-1-((4'-(trifluoromethyl)biphenyl-2-yl)methyl)-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid
CAS No.:1617540-23-4
Molecular Formula:C₂₃H₁₅F₃N₂O₃
Molecular Weight:424.379
Hs Code.:

Synonyms:1-oxo-1-((4'-(trifluoromethyl)biphenyl-2-yl)methyl)-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid

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Chemical Property of 1-oxo-1-((4'-(trifluoromethyl)biphenyl-2-yl)methyl)-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid

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Technology Process of 1-oxo-1-((4'-(trifluoromethyl)biphenyl-2-yl)methyl)-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid

There total 5 articles about 1-oxo-1-((4'-(trifluoromethyl)biphenyl-2-yl)methyl)-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.6%

: 1617540-26-7
ethyl 4-oxo-1-((4'-(trifluoromethyl)biphenyl-2-yl)methyl)-1,4-dihydro-1,5-naphthyridine-3-carboxylate

: 1617540-23-4
1-oxo-1-((4'-(trifluoromethyl)biphenyl-2-yl)methyl)-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid

Guidance literature:: With methanol; water; In dimethyl sulfoxide; at 20 ℃; for 15.5h; Inert atmosphere;

Reference yield:

: 128073-02-9
3-chloropyridine-2-carbonyl chloride

: 1617540-23-4
1-oxo-1-((4'-(trifluoromethyl)biphenyl-2-yl)methyl)-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / toluene / 12 h / 83 °C

2: potassium phosphate / N,N-dimethyl acetamide / 15 h / 74 °C / Inert atmosphere

3: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / toluene; water / 15 h / 100 °C / Inert atmosphere

4: methanol; water / dimethyl sulfoxide / 15.5 h / 20 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; methanol; potassium phosphate; water; palladium diacetate; triethylamine; In N,N-dimethyl acetamide; water; dimethyl sulfoxide; toluene;

Reference yield:

: 57266-69-0
3-chloropyridine-2-carboxylic acid

: 1617540-23-4
1-oxo-1-((4'-(trifluoromethyl)biphenyl-2-yl)methyl)-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / toluene / 20 h / 120 °C / Inert atmosphere

2: triethylamine / toluene / 12 h / 83 °C

3: potassium phosphate / N,N-dimethyl acetamide / 15 h / 74 °C / Inert atmosphere

4: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / toluene; water / 15 h / 100 °C / Inert atmosphere

5: methanol; water / dimethyl sulfoxide / 15.5 h / 20 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; methanol; potassium phosphate; thionyl chloride; water; palladium diacetate; triethylamine; In N,N-dimethyl acetamide; water; dimethyl sulfoxide; toluene;