2-<<<(p-methoxybenzyl)oxy>carbonyl>amino>ethyl 1-methyl-1H-tetrazol-5-yl disulfide

Base Information

• Chemical Name: 2-<<<(p-methoxybenzyl)oxy>carbonyl>amino>ethyl 1-methyl-1H-tetrazol-5-yl disulfide
• CAS No.: 135598-53-7
• Molecular Formula: C₁₃H₁₇N₅O₃S₂
• Molecular Weight: 355.442
• Mol file: 135598-53-7.mol

Synonyms:2-<<<(p-methoxybenzyl)oxy>carbonyl>amino>ethyl 1-methyl-1H-tetrazol-5-yl disulfide

Chemical Property of 2-<<<(p-methoxybenzyl)oxy>carbonyl>amino>ethyl 1-methyl-1H-tetrazol-5-yl disulfide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<<<(p-methoxybenzyl)oxy>carbonyl>amino>ethyl 1-methyl-1H-tetrazol-5-yl disulfide

There total 2 articles about 2-<<<(p-methoxybenzyl)oxy>carbonyl>amino>ethyl 1-methyl-1H-tetrazol-5-yl disulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.2%

bis (1-methyl-(1H)-tetrazol-5-yl)-disulfide (62671-38-9) + N-<<(p-methoxybenzyl)oxy>carbonyl>cysteamine (79310-24-0) → 2-<<<(p-methoxybenzyl)oxy>carbonyl>amino>ethyl 1-methyl-1H-tetrazol-5-yl disulfide (135598-53-7)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 0.25h;

DOI:10.1021/jo00018a056

Reference yield:

p-methoxybenzyl-S-(4,6-dimethylpyrimidin-2-yl)-thiocarbonate (41840-29-3) → 2-<<<(p-methoxybenzyl)oxy>carbonyl>amino>ethyl 1-methyl-1H-tetrazol-5-yl disulfide (135598-53-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 97.9 percent / ethyl acetate / 2 h / 20 °C

2: 94.2 percent / tetrahydrofuran / 0.25 h / 20 °C

In tetrahydrofuran; ethyl acetate;

DOI:10.1021/jo00018a056

Reference yield: 96.7%

DL-dithiothreitol (3483-12-3,6892-68-8,7634-42-6,16096-97-2,27565-41-9,35454-97-8) + 2-<<<(p-methoxybenzyl)oxy>carbonyl>amino>ethyl 1-methyl-1H-tetrazol-5-yl disulfide (135598-53-7) → (2-{(2S,3S)-2,3-Dihydroxy-4-[2-(4-methoxy-benzyloxycarbonylamino)-ethyldisulfanyl]-butyldisulfanyl}-ethyl)-carbamic acid 4-methoxy-benzyl ester (135598-55-9)

Guidance literature:

In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jo00018a056

upstream raw materials:

bis (1-methyl-(1H)-tetrazol-5-yl)-disulfide

N-<<(p-methoxybenzyl)oxy>carbonyl>cysteamine

p-methoxybenzyl-S-(4,6-dimethylpyrimidin-2-yl)-thiocarbonate

Downstream raw materials:

(2-{(2S,3S)-2,3-Dihydroxy-4-[2-(4-methoxy-benzyloxycarbonylamino)-ethyldisulfanyl]-butyldisulfanyl}-ethyl)-carbamic acid 4-methoxy-benzyl ester

{2-[2-(4-Methoxy-benzyloxycarbonylamino)-ethyldisulfanyl]-ethyl}-carbamic acid 4-methoxy-benzyl ester