10-(2,4-dimethoxybenzyl)-7-oxo-5-phenyl-1,1,3,(S)-3a,4,5,7,10-octahydro-5,10,11,11b-tetraazacyclopenta[a]anthracene-8-carboxylic acid

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Chemical Name:10-(2,4-dimethoxybenzyl)-7-oxo-5-phenyl-1,1,3,(S)-3a,4,5,7,10-octahydro-5,10,11,11b-tetraazacyclopenta[a]anthracene-8-carboxylic acid
CAS No.:908340-51-2
Molecular Formula:C₂₉H₂₈N₄O₅
Molecular Weight:512.565
Hs Code.:

Synonyms:10-(2,4-dimethoxybenzyl)-7-oxo-5-phenyl-1,1,3,(S)-3a,4,5,7,10-octahydro-5,10,11,11b-tetraazacyclopenta[a]anthracene-8-carboxylic acid

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Chemical Property of 10-(2,4-dimethoxybenzyl)-7-oxo-5-phenyl-1,1,3,(S)-3a,4,5,7,10-octahydro-5,10,11,11b-tetraazacyclopenta[a]anthracene-8-carboxylic acid

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Technology Process of 10-(2,4-dimethoxybenzyl)-7-oxo-5-phenyl-1,1,3,(S)-3a,4,5,7,10-octahydro-5,10,11,11b-tetraazacyclopenta[a]anthracene-8-carboxylic acid

There total 4 articles about 10-(2,4-dimethoxybenzyl)-7-oxo-5-phenyl-1,1,3,(S)-3a,4,5,7,10-octahydro-5,10,11,11b-tetraazacyclopenta[a]anthracene-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 908340-50-1
1-(2,4-dimethoxybenzyl)-6-fluoro-4-oxo-7-[(S)-2-phenylaminomethylpyrrolidin-1-yl]-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid

: 908340-51-2
10-(2,4-dimethoxybenzyl)-7-oxo-5-phenyl-1,1,3,(S)-3a,4,5,7,10-octahydro-5,10,11,11b-tetraazacyclopenta[a]anthracene-8-carboxylic acid

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 100 ℃; for 16h;
DOI:10.1021/jm060010w

Reference yield:

: 908340-49-8
1-(2,4-dimethoxybenzyl)-6-fluoro-4-oxo-7-[(S)-2-phenylaminomethylpyrrolidin-1-yl]-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid ethyl ester

: 908340-51-2
10-(2,4-dimethoxybenzyl)-7-oxo-5-phenyl-1,1,3,(S)-3a,4,5,7,10-octahydro-5,10,11,11b-tetraazacyclopenta[a]anthracene-8-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / aq. LiOH / ethanol / 24 h

2: 83 percent / NaH / dimethylformamide / 16 h / 100 °C

With lithium hydroxide; sodium hydride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm060010w

Reference yield:

: 64030-44-0
(2S)-2-(anilinomethyl)pyrrolidine

: 908340-51-2
10-(2,4-dimethoxybenzyl)-7-oxo-5-phenyl-1,1,3,(S)-3a,4,5,7,10-octahydro-5,10,11,11b-tetraazacyclopenta[a]anthracene-8-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / iPr₂EtN / acetonitrile / 72 h / 20 °C

2: 90 percent / aq. LiOH / ethanol / 24 h

3: 83 percent / NaH / dimethylformamide / 16 h / 100 °C

With lithium hydroxide; sodium hydride; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm060010w