64030-44-0

Usage

Chemical Properties

Clear colorless viscous liquid

InChI:InChI=1/C11H16N2/c1-2-5-10(6-3-1)13-9-11-7-4-8-12-11/h1-3,5-6,11-13H,4,7-9H2/t11-/m0/s1

Upstream product

• 917-64-6 methyl magnesium iodide 
• 85148-23-8 3-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-1-((S)-2-phenyl-hexahydro-pyrrolo[1,2-c]imidazol-3-yl)-propan-1-one 
• 141-78-6 ethyl acetate 
• 81968-47-0 phenyl-(2-phenyl-hexahydro-pyrrolo[1,2-c]imidazol-3-yl)-methanone 
• 105-36-2 ethyl bromoacetate 
• 25746-83-2 (2S)-N-phenylpyrrolidine-2-carboxamide 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 71350-58-8 methoxycarbonyl aminal 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 62-53-3 aniline 
• 64030-42-8 benzyl (2S)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate 
• 56-86-0 L-glutamic acid 
• 511543-55-8 (2R,5S)-2-trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octane-4,8-dione 
• 220510-58-7 tert-butyl (S)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate 

Downstream Products

• 110638-52-3 (3S,7aS)-1,2,5,6,7,7a-hexahydro-3-morpholino-2-phenylpyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide 
• 110715-38-3 (3R,7aS)-1,2,5,6,7,7a-hexahydro-3-morpholino-2-phenylpyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide 
• 261162-68-9 (1S,3aS)-1-Phenoxy-2-phenyl-hexahydro-pyrrolo[1,2-c][1,3,2]diazaphosphole 1-oxide 
• 735278-45-2 1-phenoxy-2-phenyl-hexahydro-pyrrolo[1,2-c][1,3,2]diazaphopsphole 
• 851487-54-2 2-phenyl-hexahydro-pyrrolo[1,2-c]imidazole-3-thione 

Relevant academic research and scientific papers

Chiral azo-heterocyclic carbene precursor compound with bicyclic framework and preparation method thereof

The invention discloses a chiral azo-heterocyclic carbene precursor compound with a bicyclic framework and a preparation method thereof. A series of the chiral azo-heterocyclic carbene precursor compound with the bicyclic framework is obtained by taking c

Modular synthesis of new bicyclic carbene precursors

A series of new N-heterocyclic carbene (NHC) precursors, containing bicyclic pyrrolo[1,2-c]imidazole framework, were prepared from N-(tert-butoxycarbonyl)-L-proline (1-Boc-L-proline). The sequential attachment of nitrogen nucleophiles and subsequent ring

Transfer hydrogenation reactions catalyzed by chiral half-sandwich Ruthenium complexes derived from Proline

Chiral ruthenium half-sandwich complexes were prepared using a chelating diamine made from proline with a phenyl, ethyl, or benzyl group, instead of hydrogen on one of the coordinating arms. Three of these complexes were obtained as single diastereoisomers and their configuration identified by X-ray crystallography. The complexes are recyclable catalysts for the reduction of ketones to chiral alcohols in water. A ruthenium hydride species is identified as the active species by NMR spectroscopy and isotopic labelling experiments. Maximum enantio-selectivity was attained when a phenyl group was directly attached to the primary amine on the diamine ligand derived from proline. [Figure not available: see fulltext.]

Synthesis and characterization of new chiral azolinium salts, precursors to N-heterocyclic carbenes, derived from l-proline

A short and flexible procedure for the preparation of seven chiral azolinium and five functionalized chiral azolinium salts, precursors to N-heterocyclic carbenes, derived from l-proline has been developed. Moderate to good overall yields were obtained. Some NHC dimers and thiones were isolated. X-ray crystal structure determinations of two [Rh-NHC] complexes were also reported.

Chiral amine catalyzed enantio- and diastereoselective Michael reaction in brine

Simple pyrrolidine-based chiral amines were synthesized and used for the Michael addition of different ketones to a variety of nitro-olefins in brine. The effect of different surfactants and acids on the yields and stereochemical outcome of the Michael ad

Enantiomerically pure cyclopalladated diazaphospholidine

Enantiomerically pure (S)-2-(anilinomethyl)pyrrolidine (S)-2 was obtained from (S)-proline using a modified four-step procedure in a total yield of 56%. Diamine (S)-2 was converted to diazaphospholidine (S)-1 using oTolP(NMe2)2

Synthesis and characterization of chiral 1,2-diamines from 5-oxo-pyrrolidine-(S)-2-carboxylic acid

Unsymmetrical chiral secondary vicinal diamines were synthesized by applying a modified three-step reaction. The key step in this sequence is a primary amine mediated ring opening reaction of a diastereomeric oxazolidinone derivative. A possible mechanism

Method for preparing 2-(2-arylmorpholin-2-yl)ethanol derivatives and intermediates

The invention relates to a process for the preparation of substituted 2-(2-arylmorpholin-2-yl)ethanol derivatives.

Conformational arm-wrestling: Battles for stereochemical control in benzamides bearing matched and mismatched chiral 2- and 6-substituents

The orientation of a tertiary amide group adjacent to an aromatic ring may be governed by the stereochemistry of an adjacent chiral substituent. With a chiral substituent in both ortho positions, matched/mismatched pairs of isomers result. Evidence for ma

Synthesis and application to asymmetric allylic amination of substituted monodonor diazaphospholidine ligands

The synthesis of a series of substituted monodonor diazaphospholidine ligands is described. A regioselective lithiation process is a key step in one of these syntheses. The compounds are designed to be incorporated into soluble polymer and other solid pha