2,4-bis(2,5-dimethoxyphenyl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole

Base Information

Chemical Name:2,4-bis(2,5-dimethoxyphenyl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole
CAS No.:1396162-07-4
Molecular Formula:C₂₅H₃₄N₂O₅Si
Molecular Weight:470.641
Hs Code.:

Synonyms:2,4-bis(2,5-dimethoxyphenyl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole

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Chemical Property of 2,4-bis(2,5-dimethoxyphenyl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole

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Technology Process of 2,4-bis(2,5-dimethoxyphenyl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole

There total 4 articles about 2,4-bis(2,5-dimethoxyphenyl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1395048-09-5
4-bromo-2-(2,5-dimethoxyphenyl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole

: 107099-99-0
2,5-dimethoxyphenylboronic acid

: 1396162-07-4
2,4-bis(2,5-dimethoxyphenyl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In methanol; toluene; at 90 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.ejps.2011.11.004

Reference yield:

: 107099-99-0
2,5-dimethoxyphenylboronic acid

: 1396162-07-4
2,4-bis(2,5-dimethoxyphenyl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / methanol; toluene / 16 h / 90 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.02 h / -78 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / methanol; toluene / 16 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; In tetrahydrofuran; methanol; hexane; toluene; 1.1: Suzuki coupling / 3.1: Suzuki coupling;
DOI:10.1016/j.ejps.2011.11.004

Reference yield:

: 159590-01-9
2,4,5-tribromo-1-<<2-(trimethylsilyl)ethoxy>methyl>-1H-imidazole

: 1396162-07-4
2,4-bis(2,5-dimethoxyphenyl)-1-{[2-(1,1,1-trimethylsilyl)ethoxy]methyl}-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / methanol; toluene / 16 h / 90 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.02 h / -78 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / methanol; toluene / 16 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; In tetrahydrofuran; methanol; hexane; toluene; 1.1: Suzuki coupling / 3.1: Suzuki coupling;
DOI:10.1016/j.ejps.2011.11.004