tert-butyl (2S,5R)-2-(4-{[(6-aminopyridin-2-yl)methyl](methyl)carbamoyl}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (2S,5R)-2-(4-{[(6-aminopyridin-2-yl)methyl](methyl)carbamoyl}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-pyrrolidine-1-carboxylate
CAS No.:1269615-44-2
Molecular Formula:C₃₇H₅₂N₄O₄Si
Molecular Weight:644.93
Hs Code.:

tert-butyl (2S,5R)-2-(4-{[(6-aminopyridin-2-yl)methyl](methyl)carbamoyl}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-pyrrolidine-1-carboxylate

Synonyms:tert-butyl (2S,5R)-2-(4-{[(6-aminopyridin-2-yl)methyl](methyl)carbamoyl}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (2S,5R)-2-(4-{[(6-aminopyridin-2-yl)methyl](methyl)carbamoyl}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (2S,5R)-2-(4-{[(6-aminopyridin-2-yl)methyl](methyl)carbamoyl}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-pyrrolidine-1-carboxylate

There total 20 articles about tert-butyl (2S,5R)-2-(4-{[(6-aminopyridin-2-yl)methyl](methyl)carbamoyl}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1269615-54-4
tert-butyl (2R,5S)-2-(4-{[(6-bromopyridin-2-yl)methyl](methyl)carbamoyl}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-pyrrolidine-1-carboxylate

: 1269615-44-2
tert-butyl (2S,5R)-2-(4-{[(6-aminopyridin-2-yl)methyl](methyl)carbamoyl}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-pyrrolidine-1-carboxylate

Guidance literature:: With ammonium hydroxide; caesium carbonate; copper(l) iodide; acetylacetone; In N,N-dimethyl-formamide; at 90 ℃; for 16h; Inert atmosphere; Sealed tube;

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 1269615-44-2
tert-butyl (2S,5R)-2-(4-{[(6-aminopyridin-2-yl)methyl](methyl)carbamoyl}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper(l) iodide / N,N-dimethyl-formamide / 6 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.1: platinum(II) chloride / toluene / 6 h / 80 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

6.1: triethylamine / palladium diacetate / 120 °C

7.1: water; lithium hydroxide / methanol / 20 °C

7.2: pH 4.5

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C

9.1: ammonium hydroxide; caesium carbonate / copper(l) iodide; acetylacetone / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere; Sealed tube

With ammonium hydroxide; water; sodium tris(acetoxy)borohydride; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; acetylacetone; platinum(II) chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1190391-64-0
4-methoxybenzyl {(1R)-1-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]pent-4-yn-1-yl}carbamate

: 1269615-44-2
tert-butyl (2S,5R)-2-(4-{[(6-aminopyridin-2-yl)methyl](methyl)carbamoyl}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper(l) iodide / N,N-dimethyl-formamide / 6 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.1: platinum(II) chloride / toluene / 6 h / 80 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

6.1: triethylamine / palladium diacetate / 120 °C

7.1: water; lithium hydroxide / methanol / 20 °C

7.2: pH 4.5

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C

9.1: ammonium hydroxide; caesium carbonate / copper(l) iodide; acetylacetone / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere; Sealed tube

With ammonium hydroxide; water; sodium tris(acetoxy)borohydride; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; acetylacetone; platinum(II) chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;