(2R)-1-[(2-tetrahydropyranyl)oxy]-2-[(tert-butyloxycarbonyl)amino]-3-(phenylsulfonyl)-5-hexene

Base Information

Chemical Name:(2R)-1-[(2-tetrahydropyranyl)oxy]-2-[(tert-butyloxycarbonyl)amino]-3-(phenylsulfonyl)-5-hexene
CAS No.:187409-29-6
Molecular Formula:C₂₂H₃₃NO₆S
Molecular Weight:439.573
Hs Code.:

Synonyms:(2R)-1-[(2-tetrahydropyranyl)oxy]-2-[(tert-butyloxycarbonyl)amino]-3-(phenylsulfonyl)-5-hexene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-1-[(2-tetrahydropyranyl)oxy]-2-[(tert-butyloxycarbonyl)amino]-3-(phenylsulfonyl)-5-hexene

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Technology Process of (2R)-1-[(2-tetrahydropyranyl)oxy]-2-[(tert-butyloxycarbonyl)amino]-3-(phenylsulfonyl)-5-hexene

There total 1 articles about (2R)-1-[(2-tetrahydropyranyl)oxy]-2-[(tert-butyloxycarbonyl)amino]-3-(phenylsulfonyl)-5-hexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 116611-45-1
(2R)-2-t-butoxycarbonylamino-3-phenylsulfonyl-1-(2-tetrahydropyranyloxy)propane

: 106-95-6
allyl bromide

: 187409-29-6
(2R)-1-[(2-tetrahydropyranyl)oxy]-2-[(tert-butyloxycarbonyl)amino]-3-(phenylsulfonyl)-5-hexene

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; 1.) -78 deg C, 15 min, 2.) -78 deg C -> 0 deg C, 2.5 h;
DOI:10.1021/jo961790r

Reference yield:

: 187409-29-6
(2R)-1-[(2-tetrahydropyranyl)oxy]-2-[(tert-butyloxycarbonyl)amino]-3-(phenylsulfonyl)-5-hexene

: 123724-22-1
N-<(tert-butyloxy)carbonyl>-trans-3-n-propyl-L-proline

Guidance literature:: Multi-step reaction with 3 steps

2: 86 percent / CrO₃, H₂SO₄ / acetone / 1 h / Ambient temperature

3: 89 percent / H₂ / Pd/C / methanol / 0.5 h

With chromium(VI) oxide; sulfuric acid; hydrogen; palladium on activated charcoal; In methanol; acetone;
DOI:10.1021/jo961790r

Reference yield:

: 103935-47-3
2-bromoethyl triflate

: 187409-29-6
(2R)-1-[(2-tetrahydropyranyl)oxy]-2-[(tert-butyloxycarbonyl)amino]-3-(phenylsulfonyl)-5-hexene

: (2R)-1-(tert-butyloxycarbonyl)-2-{[(2-tetrahydropyranyl)oxy]methyl}-3-allyl-3-(phenylsulfonyl)pyrrolidine

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, -50 deg C, 30 min, 2.) THF, hexane, -78 deg C -> 0 deg C, 2.5 h;
DOI:10.1021/jo961790r