103935-47-3 Usage
Description
2-Bromoethyl trifluoromethanesulphonate, with the chemical formula C4H6BrF3O3S, is a highly reactive and toxic chemical compound. It is widely recognized for its role as a reagent in organic synthesis, particularly for the functionalization of alcohols and amines. Its primary function is as an alkylating agent, enabling the formation of carbon-carbon or carbon-nitrogen bonds through its reaction with nucleophilic functional groups.
Uses
Used in Organic Synthesis:
2-Bromoethyl trifluoromethanesulphonate is used as an alkylating agent in organic synthesis for the functionalization of alcohols and amines. It facilitates the formation of carbon-carbon or carbon-nitrogen bonds, which is crucial for the synthesis of various organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Bromoethyl trifluoromethanesulphonate is utilized for the synthesis of a range of drugs. Its alkylating properties are harnessed to create new drug molecules with specific therapeutic effects.
Used in Polymer Production:
2-Bromoethyl trifluoromethanesulphonate also serves as a cross-linking agent in the production of polymers. It helps in creating stable polymer structures by forming covalent bonds between polymer chains, enhancing the material's properties such as strength and durability.
Safety Precautions:
Given its toxic and corrosive nature, it is imperative to handle 2-Bromoethyl trifluoromethanesulphonate with extreme care. Adequate safety measures, including the use of personal protective equipment and proper disposal methods, must be implemented to minimize exposure and potential hazards.
Check Digit Verification of cas no
The CAS Registry Mumber 103935-47-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,9,3 and 5 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 103935-47:
(8*1)+(7*0)+(6*3)+(5*9)+(4*3)+(3*5)+(2*4)+(1*7)=113
113 % 10 = 3
So 103935-47-3 is a valid CAS Registry Number.
103935-47-3Relevant articles and documents
Vinyl Thianthrenium Tetrafluoroborate: A Practical and Versatile Vinylating Reagent Made from Ethylene
Juliá, Fabio,Yan, Jiyao,Paulus, Fritz,Ritter, Tobias
supporting information, p. 12992 - 12998 (2021/09/03)
The use of vinyl electrophiles in synthesis has been hampered by the lack of access to a suitable reagent that is practical and of appropriate reactivity. In this work we introduce a vinyl thianthrenium salt as an effective vinylating reagent. The bench-stable, crystalline reagent can be readily prepared from ethylene gas at atmospheric pressure in one step and is broadly useful in the annulation chemistry of (hetero)cycles, N-vinylation of heterocyclic compounds, and palladium-catalyzed cross-coupling reactions. The structural features of the thianthrene core enable a distinct synthesis and reactivity profile, unprecedented for other vinyl sulfonium derivatives.
SPIRO-SULFONIMIDAMIDE DERIVATIVES AS INHIBITORS OF MYELOID CELL LEUKEMIA-1 (MCL-1) PROTEIN
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Paragraph 00437; 00439, (2021/10/22)
The disclosure is directed to compounds of Formula (I). Pharmaceutical compositions comprising compounds of Formula (I) as well as methods of their use and preparation, are also described.
TRIOXACARCIN-ANTIBODY CONJUGATES AND USES THEREOF
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Paragraph 00474; 00477, (2019/02/25)
Provided herein are trioxacarcin-antibody drug conjugates of Formula (I): and pharmaceutically acceptable salts thereof, wherein R7 is -L-B, wherein L is a linking group, and B is an antibody or antibody fragment. Also provided are methods of preparing the antibody-drug conjugates, pharmaceutically acceptable compositions thereof, and methods of their use and treatment. Further provided are precursors to the trioxacarcin- antibody drug conjugates (e.g., compounds of Formula (II), novel trioxacarcins without an antibody conjugated thereto), pharmaceutical compositions thereof, and methods of their use and treatment.