(R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-yl 3-methylbut-3-enoate

Base Information

Chemical Name:(R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-yl 3-methylbut-3-enoate
CAS No.:1630067-59-2
Molecular Formula:C₂₀H₂₈O₅
Molecular Weight:348.439
Hs Code.:

Synonyms:(R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-yl 3-methylbut-3-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-yl 3-methylbut-3-enoate

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Technology Process of (R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-yl 3-methylbut-3-enoate

There total 1 articles about (R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-yl 3-methylbut-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.9%

: 1617-31-8
3-methylbut-3-enoic acid

: 1630067-58-1
(R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-ol

: 1630067-59-2
(R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-yl 3-methylbut-3-enoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 5.16667h; Inert atmosphere;
DOI:10.1002/ejoc.201402452

Reference yield: 90.7%

: 1630067-59-2
(R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-yl 3-methylbut-3-enoate

: 1630067-60-5
(2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-(methoxymethoxy)-2-(prop-1-en-2-yl)hex-4-enoic acid

Guidance literature:: With chloro-trimethyl-silane; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; at -78 - -20 ℃; for 2.83333h; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201402452

Reference yield:

: 1630067-59-2
(R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-yl 3-methylbut-3-enoate

: 487-79-6
(-)-kainic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: chloro-trimethyl-silane; lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 2.83 h / -78 - -20 °C / Inert atmosphere

2.1: di-tert-butyl dicarbonate; pyridine / ethyl acetate / 3 h / 20 °C / Inert atmosphere

2.2: 2 h / Inert atmosphere

3.1: aluminum (III) chloride; lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 12 h / 0 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

5.1: hydrogenchloride / methanol / 9.17 h / 0 - 20 °C / Inert atmosphere

6.1: dichloro bis(acetonitrile) palladium(II) / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

7.1: iodine / dichloromethane / 0 - 20 °C / Inert atmosphere

7.2: 0.5 h / -78 - 0 °C / Inert atmosphere

8.1: chloro-trimethyl-silane; zinc / ethanol; ethylene dibromide / 0.08 h / 75 °C / Inert atmosphere

8.2: 2 h / 75 °C / Inert atmosphere

9.1: Jones reagent / acetone / 0 - 20 °C / Inert atmosphere

10.1: sodium hydroxide / water; diethyl ether / 17.5 h / 100 °C / Inert atmosphere

With pyridine; hydrogenchloride; aluminum (III) chloride; dichloro bis(acetonitrile) palladium(II); lithium aluminium tetrahydride; chloro-trimethyl-silane; di-tert-butyl dicarbonate; Jones reagent; iodine; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; ethylene dibromide; acetone; 9.1: |Jones Oxidation;
DOI:10.1002/ejoc.201402452