N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-fluorobenzenesulfonamide

Base Information

Chemical Name:N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-fluorobenzenesulfonamide
CAS No.:1345822-16-3
Molecular Formula:C₂₀H₂₀FN₃O₃S₂
Molecular Weight:433.528
Hs Code.:

Synonyms:N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-fluorobenzenesulfonamide

Suppliers and Price of N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-fluorobenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-fluorobenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-fluorobenzenesulfonamide

There total 3 articles about N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 1345822-06-1
C₁₄H₁₇N₃OS

: 1345822-16-3
N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-fluorobenzenesulfonamide

Guidance literature:: With triethylamine; In ethyl acetate; N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1016/j.ejmech.2011.09.025

Reference yield:

: 98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

: 1345822-16-3
N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / methanol / 2 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

3: triethylamine / ethyl acetate; N,N-dimethyl-formamide / 8 h / 20 °C

With triethylamine; trifluoroacetic acid; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.09.025

Reference yield:

: 1345822-04-9
C₁₉H₂₅N₃O₃S

: 1345822-16-3
N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

2.1: triethylamine / ethyl acetate; N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

2.2: 8 h / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.2174/1573406410666140218103022