2-(2-azabicyclo[2.2.1]heptan-5-yloxy)-4-[3-(methoxymethyl)-8-azabicyclo[3.2.1]octan-8-yl]-N,N-dimethyl-5-phenyl-thieno[2,3-d]pyrimidine-6-carboxamide

Base Information

Chemical Name:2-(2-azabicyclo[2.2.1]heptan-5-yloxy)-4-[3-(methoxymethyl)-8-azabicyclo[3.2.1]octan-8-yl]-N,N-dimethyl-5-phenyl-thieno[2,3-d]pyrimidine-6-carboxamide
CAS No.:1437774-04-3
Molecular Formula:C₃₀H₃₇N₅O₃S
Molecular Weight:547.721
Hs Code.:

Synonyms:2-(2-azabicyclo[2.2.1]heptan-5-yloxy)-4-[3-(methoxymethyl)-8-azabicyclo[3.2.1]octan-8-yl]-N,N-dimethyl-5-phenyl-thieno[2,3-d]pyrimidine-6-carboxamide

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Chemical Property of 2-(2-azabicyclo[2.2.1]heptan-5-yloxy)-4-[3-(methoxymethyl)-8-azabicyclo[3.2.1]octan-8-yl]-N,N-dimethyl-5-phenyl-thieno[2,3-d]pyrimidine-6-carboxamide

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Technology Process of 2-(2-azabicyclo[2.2.1]heptan-5-yloxy)-4-[3-(methoxymethyl)-8-azabicyclo[3.2.1]octan-8-yl]-N,N-dimethyl-5-phenyl-thieno[2,3-d]pyrimidine-6-carboxamide

There total 6 articles about 2-(2-azabicyclo[2.2.1]heptan-5-yloxy)-4-[3-(methoxymethyl)-8-azabicyclo[3.2.1]octan-8-yl]-N,N-dimethyl-5-phenyl-thieno[2,3-d]pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1437774-92-9
tert-butyl 5-[6-(dimethylcarbamoyl)-4-[3-(methoxymethyl)-8-azabicyclo[3.2.1]octan-8-yl]-5-phenyl-thieno[2,3-d]pyrimidin-2-yl]oxy-2-azabicyclo[2.2.1]heptane-2-carboxylate

: 1437774-04-3
2-(2-azabicyclo[2.2.1]heptan-5-yloxy)-4-[3-(methoxymethyl)-8-azabicyclo[3.2.1]octan-8-yl]-N,N-dimethyl-5-phenyl-thieno[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h;

Reference yield:

: 76872-27-0
2,4-dichloro-5-phenyl-thieno[2,3-d]pyrimidine

: 1437774-04-3
2-(2-azabicyclo[2.2.1]heptan-5-yloxy)-4-[3-(methoxymethyl)-8-azabicyclo[3.2.1]octan-8-yl]-N,N-dimethyl-5-phenyl-thieno[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1 h / -55 °C / Inert atmosphere

1.2: 4 h / -55 - 20 °C

2.1: triethylamine / ethanol; dichloromethane / 5 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.05 h / Inert atmosphere

3.2: 1.5 h / 70 °C

4.1: formic acid / methanol

5.1: triethylamine; HATU / acetonitrile; tetrahydrofuran / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h

With n-butyllithium; formic acid; sodium hydride; triethylamine; diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; acetonitrile; mineral oil;

Reference yield:

: C₃₄H₄₂N₄O₆S

: 1437774-04-3
2-(2-azabicyclo[2.2.1]heptan-5-yloxy)-4-[3-(methoxymethyl)-8-azabicyclo[3.2.1]octan-8-yl]-N,N-dimethyl-5-phenyl-thieno[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: formic acid / methanol

2: triethylamine; HATU / acetonitrile; tetrahydrofuran / 20 °C

3: trifluoroacetic acid / dichloromethane / 2 h

With formic acid; triethylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;