76872-27-0

Basic information

• Product Name: 2,4-Dichloro-5-phenylthieno[2,3-d]pyriMidine
• Synonyms: 2,4-Dichloro-5-phenylthieno[2,3-d]pyriMidine
• CAS NO: 76872-27-0
• Molecular Formula: C₁₂H₆Cl₂N₂S
• Molecular Weight: 281.16044
• Mol File: 76872-27-0.mol

Chemical Properties

• Melting Point: 157-158 °C(Solv: acetone (67-64-1))
• Boiling Point: 409.7±37.0 °C(Predicted)
• Appearance: /
• Density: 1.490±0.06 g/cm3(Predicted)
• PKA: -0.92±0.40(Predicted)
• CAS DataBase Reference: 2,4-Dichloro-5-phenylthieno[2,3-d]pyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichloro-5-phenylthieno[2,3-d]pyriMidine(76872-27-0)
• EPA Substance Registry System: 2,4-Dichloro-5-phenylthieno[2,3-d]pyriMidine(76872-27-0)

Safety Data

• Hazardous Substances Data: 76872-27-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,4-Dichloro-5-phenylthieno[2,3-d]pyrimidine is used as a key intermediate in organic synthesis for the preparation of various complex organic molecules. Its unique structure allows for further functionalization and modification, enabling the synthesis of a wide range of compounds with diverse properties and applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2,4-Dichloro-5-phenylthieno[2,3-d]pyrimidine serves as a valuable building block for the development of pharmaceuticals. Its potential biological activity, such as inhibiting certain enzymes and receptors, makes it a promising candidate for the design and synthesis of novel therapeutic agents.
Used in Pharmaceutical Development:
2,4-Dichloro-5-phenylthieno[2,3-d]pyrimidine is employed as a starting material for the synthesis of pharmaceuticals with potential therapeutic applications. Its unique structure and properties contribute to the discovery of new drugs with improved efficacy, selectivity, and safety profiles.
Used in Agrochemical Development:
2,4-Dichloro-5-phenylthieno[2,3-d]pyriMidine is also utilized in the development of agrochemicals, such as pesticides and herbicides. Its potential biological activity against pests and weeds makes it a valuable component in the design of novel agrochemicals with enhanced performance and reduced environmental impact.

Upstream product

• 17277-47-3 (Z)-2-cyano-3-phenylbut-2-enoic acid ethyl ester 
• 98-86-2 acetophenone 
• 4815-36-5 ethyl 2-amino-4-phenyl-thiophene-3-carboxylate 
• 76872-75-8 5-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 1401985-61-2 (S)-1-{5-phenyl-4-[(pyridin-2-ylmethyl)amino]thieno[2,3-d]pyrimidin-2-yl}piperidine-3-carboxylic acid 
• 1401985-49-6 N-(2-hydroxyethyl)-1-{5-phenyl-4-[(pyridin-2-ylmethyl)amino]thieno[2,3-d]pyrimidin-2-yl}piperidine-3-carboxamide 
• 1401985-56-5 (3S)-N-(2-hydroxyethyl)-1-{5-phenyl-4-[(pyridin-2-ylmethyl)amino]thieno[2,3-d]pyrimidin-2-yl}piperidine-3-carboxamide 
• 76872-51-0 2-Chloro-5-phenyl-3,4-dihydro-thieno[2,3-d]pyrimidine 
• 1437774-70-3 8-(2-chloro-5-phenyl-thieno[2,3-d]pyrimidin-4-yl)-3-oxa-8-azabicyclo[3.2.1]octane 
• 1216203-46-1 4-(2-chloro-5-phenyl-thieno[2,3-d]pyrimidin-4-yl)morpholine 
• 1437774-59-8 [1-(2-chloro-5-phenyl-thieno[2,3-d]pyrimidin-4-yl)-4-piperidyl]methanol 
• 1437774-89-4 methyl 2,4-dichloro-5-phenyl-thieno[2,3-d]pyrimidine-6-carboxylate 
• 1437774-72-5 6-bromo-2-chloro-5-phenyl-thieno[2,3-d]pyrimidine 
• 1437773-88-0 8-[2-(2-azabicyclo[2.2.1]heptan-5-yloxy)-5-phenyl-thieno[2,3-d]pyrimidin-4-yl]-3-oxa-8-azabicyclo[3.2.1]octane 
• 1437774-71-4 tert-butyl 5-[4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5-phenyl-thieno[2,3-d]pyrimidin-2-yl]oxy-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 1437772-09-2 [8-(4-morpholino-5-phenyl-thieno[2,3-d]pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl]methanol 
• 1437771-94-2 5-phenyl-2-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-d]pyrimidine 
• 1225701-41-6 2-chloro-5-phenyl-thieno[2,3-d]pyrimidine 

Relevant articles and documents

ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF

Provided herein are small molecule modulators of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

THIENO [2, 3-D] PYRIMIDINE DERIVATIVES AND THEIR USE TO TREAT ARRHYTHMIA

The present invention relates to thienopyrimidine compounds which are potassium channel inhibitors. Pharmaceutical compositions comprising the compounds and their use in the treatment of arrhythmia are also described.

THIENO [2, 3 -D] PYRIMIDINE DERIVATIVES AND THEIR USE TO TREAT ARRHYTHMIA

The present invention relates to thienopyrimidine compounds which are potassium channel inhibitors. Pharmaceutical compositions comprising the compounds and their use in the treatment of arrhythmia are also described.

THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS

The present invention provides thienopyrimidine compounds which are potasium channels inhibitors. Pharmaceutical compositions comprising the compounds and their use in the treatment of arrhythmia are also provided.

Cyclic Guanidines. 14. Imidazothienopyrimidin-2-one Derivatives as Blood Platelet Aggregation Inhibitors

A series of novel 1,2,3,5-tetrahydroimidazothieno-, --, and -pyrimidin-2-one derivatives has been prepared and tested for the activity of inhibiting platelet aggregation in rats in vitro and ex vivo.These compounds were synthes